ArticleVascular health and risk management2008
Characterization of the vasodilatory action of testosterone in the human pulmonary circulation.
Article in Vascular health and risk management, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for "Sex Differences in Health Awareness Day".Biology of sex differences · 2025Review
- Neuroendocrine contribution to sex-related variations in adverse air pollution health effects.Journal of toxicology and environmental health. Part B, Critical reviews · 2024Review
- Sex-biased TGFβ signalling in pulmonary arterial hypertension.Cardiovascular research · 2023Review
- Newer insights into the pathobiological and pharmacological basis of the sex disparity in patients with pulmonary arterial hypertension.American journal of physiology. Lung cellular and molecular physiology · 2021Review
- An Intramuscular Injection of Mixed Testosterone Esters Does Not Acutely Enhance Strength and Power in Recreationally Active Young Men.Frontiers in physiology · 2020Article
- Sex, Gender, and Sex Hormones in Pulmonary Hypertension and Right Ventricular Failure.Comprehensive Physiology · 2019Review
- Basic Science Evidence for the Link Between Erectile Dysfunction and Cardiometabolic Dysfunction.The journal of sexual medicine · 2015Review
- Sex and menopause differences in response to tadalafil: 6-minute walk distance and time to clinical worsening.Pulmonary circulation · 2015Article
- Crucial role of androgen receptor in vascular H2S biosynthesis induced by testosterone.British journal of pharmacology · 2015Article
- Sex differences in the pulmonary circulation: implications for pulmonary hypertension.American journal of physiology. Heart and circulatory physiology · 2014Review
- Pulmonary arterial hypertension: basis of sex differences in incidence and treatment response.British journal of pharmacology · 2014Review
- Sex differences and sex steroids in lung health and disease.Endocrine reviews · 2012Review
- Estrogens and development of pulmonary hypertension: interaction of estradiol metabolism and pulmonary vascular disease.Journal of cardiovascular pharmacology · 2010Review
- Pulmonary hypertension in women.Expert review of cardiovascular therapy · 2010Review
- Development of pulmonary arterial hypertension in women: interplay of sex hormones and pulmonary vascular disease.Women's health (London, England) · 2010Review
- The genetics of pulmonary arterial hypertension in the post-BMPR2 era.Pulmonary circulationArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess for the first time the vasodilatory effect of testosterone in the human pulmonary circulation utilizing both isolated human pulmonary arteries and isolated perfused human lungs. In addition, a secondary aim was to determine whether there was any difference in the response to testosterone dependent upon gender.
methodsIsolated human pulmonary arteries were studied by wire myography. Vessels were preconstricted with U46619 (1 nM-1 microM) prior to exposing them to either testosterone (1 nM-100 microM) or ethanol vehicle (<0.1%). Isolated lungs were studied in a ventilated and perfused model. They were exposed to KCl (100 mM), prior to the addition of either testosterone (1 nM-100 microM) or ethanol vehicle (<0.1%).
resultsTestosterone caused significant vasodilatation in all preparations, but a greater response to testosterone was observed in the isolated perfused lungs, 24.9 +/- 2.2% at the 100 microM dose of testosterone in the isolated pulmonary arteries compared to 100 +/- 13.6% at the 100 microM dose in the isolated perfused lungs. No significant differences in the response to testosterone were observed between sexes.
conclusionTestosterone is an efficacious vasodilator in the human pulmonary vasculature and this is not modulated by patient sex. This vasodilator action suggests that testosterone therapy may be beneficial to male patients with pulmonary arterial hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.