ArticleVascular health and risk management2008
Dual factor pulse pressure: body mass index and outcome in type 2 diabetic subjects on maintenance hemodialysis. A longitudinal study 2003-2006.
Article in Vascular health and risk management, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInverse associations between risk factors and mortality have been reported in epidemiological studies of patients on maintenance hemodialysis (MHD).
objectiveThe aim of this prospective study was to estimate the effect of the dual variable pulse pressure (PP) - body mass index (BMI) on cardiovascular (CV) events and death in type 2 diabetic (T2D) subjects on MHD in a Caribbean population.
methodsEighty Afro-Caribbean T2D patients on MHD were studied prospectively from 2003 to 2006. Proportional-hazard modeling was used.
resultsOf all, 23.8% had a high PP (PP > or = 75th percentile), 76.3% had BMI < 30 Kg/m(2), 21.3% had the dual factor high PP - absence of obesity. During the study period, 23 patients died and 13 CV events occurred. In the presence of the dual variable and after adjustment for age, gender, duration of MHD, and pre-existing CV complications, the adjusted hazard ratio (HR) (95% CI) of CV events and death were respectively 2.7 (0.8-8.3); P = 0.09 and 2.4 (1.1-5.9); P = 0.04.
conclusionsThe dual factor, high PP - absence of obesity, is a prognosis factor of outcome. In type 2 diabetics on MHD, a specific management strategy should be proposed in nonobese subjects with wide pulse pressure in order to decrease or prevent the incidence of fatal and nonfatal events.
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