ReviewVascular health and risk management2008
Thrombosis in the critically ill neonate: incidence, diagnosis, and management.
Review in Vascular health and risk management, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.
- Incidence of neonatal venous thromboembolism: a systematic review and meta-analysis of the literature.Research and practice in thrombosis and haemostasis · 2026Pooled it
- Hemostatic B-knob-triggered microgels (BK-TriGs) to address bleeding in neonates.Science advances · 2026Article
- Neonatal Spontaneous Abdominal Aortic Thrombosis Associated With Hypernatremic Dehydration and Acute Renal Failure: A Case Series.Clinical case reports · 2025Article
- Review
- Neonatal Perforator Stroke: Timing, Risk Factors, and Neurological Outcome from a Single-Center Experience.Neurology international · 2025Article
- Group A Streptococcus Bacteraemia Presenting as Acute Limb Ischaemia in a Neonate: A Case Report.Cureus · 2025Article
- Article
- Neonatal Seizures as a First Sign of Inferior Vena Cava Thrombosis: Diagnostic and Therapeutic Challenges.Turkish archives of pediatrics · 2025Article
- Management of intracardiac thrombosis in newborns: a case series and a narrative review of the literature.Frontiers in cardiovascular medicine · 2025Review
- Management of Neonatal Limb Ischemia Secondary to Peripheral Arterial Lines: A Systematic Review.Journal of pediatric intensive care · 2024Review
- Diagnosis of Thrombotic Complications in Neonates Based on Photoplethysmographic Signals.Indian journal of pediatrics · 2024Article
- Sonothrombolysis: State-of-the-Art and Potential Applications in Children.Children (Basel, Switzerland) · 2023Review
- Acute aortic thrombosis following umbilical artery catheterisation in extremely low birthweight infants: walking the tight rope of management.BMJ case reports · 2023Article
- The new Italian registry of infantile thrombosis (RITI): A reflection on its journey, challenges and pitfalls.Frontiers in pediatrics · 2023Article
- Massive Saddle Pulmonary Embolism in a Preterm Neonate With Successful Emergent Open Embolectomy.CJC pediatric and congenital heart disease · 2022Article
- Intrauterine Limb Ischemia in Patient Heterozygous for the 677C>T) RS1801133 (Polymorphism of Methylenetetrahydrofolate Reductase MTHR Gene.Case reports in pediatrics · 2022Article
- Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study.Diagnostics (Basel, Switzerland) · 2021Article
- Advances in Non-Invasive Blood Pressure Monitoring.Sensors (Basel, Switzerland) · 2021Review
- Respiratory Failure in an Extremely Premature Neonate with COVID-19.Children (Basel, Switzerland) · 2021Article
- External iliac artery thrombosis: an unusual complication of femoral venous catheterisation in a neonate.BMJ case reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among children, newborn infants are most vulnerable to development of thrombosis and serious thromboembolic complications. Amongst newborns, those neonates who are critically ill, both term and preterm, are at greatest risk for developing symptomatic thromboembolic disease. The most important risk factors are inflammation, DIC, impaired liver function, fluctuations in cardiac output, and congenital heart disease, as well as exogenous risk factors such as central venous or arterial catheters. In most clinically symptomatic infants, diagnosis is made by ultrasound, venography, or CT or MRI angiograms. However, clinically asymptomatic vessel thrombosis is sometimes picked up by screening investigations or during routine imaging for other indications. Acute management of thrombosis and thromboembolism comprises a variety of approaches, including simple observation, treatment with unfractionated or low molecular weight heparin, as well as more aggressive interventions such as thrombolytic therapy or catheter-directed revascularization. Long-term follow-up is dependent on the underlying diagnosis. In the majority of infants, stabilization of the patients' general condition and hemodynamics, which allows removal of indwelling catheters, renders long-term anticoagulation superfluous. Nevertheless, in certain types of congenital heart disease or inherited thrombophilia, long-term prophylaxis may be warranted. This review article focuses on pathophysiology, diagnosis, and acute and long-term management of thrombosis in critically ill term and preterm neonates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.