ReviewVascular health and risk management2008
Role of stress fibers and focal adhesions as a mediator for mechano-signal transduction in endothelial cells in situ.
Review in Vascular health and risk management, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- The potassium channel KNature communications · 2025Article
- VopX, a novelmBio · 2025Article
- Engineered nanofibrillar collagen with tunable biophysical properties for myogenic, endothelial, and osteogenic cell guidance.Acta biomaterialia · 2024Article
- Mechanisms of pulmonary endothelial barrier dysfunction in acute lung injury and acute respiratory distress syndrome.Chinese medical journal pulmonary and critical care medicine · 2024Article
- Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro.International journal of molecular sciences · 2023Review
- Mechanomorphological Guidance of Colloidal Gel Regulates Cell Morphogenesis.Macromolecular bioscience · 2023Article
- Mechanotransduction in Endothelial Cells in Vicinity of Cancer Cells.Cellular and molecular bioengineering · 2022Article
- Lymphoedema conditions disrupt endothelial barrier functionJournal of the Royal Society, Interface · 2022Article
- Flow-induced glycocalyx formation and cell alignment of HUVECs compared to iPSC-derived ECs for tissue engineering applications.Frontiers in cell and developmental biology · 2022Article
- The Important Role of Endothelium and Extracellular Vesicles in the Cellular Mechanism of Aortic Aneurysm Formation.International journal of molecular sciences · 2021Review
- FAK-Dependent Cell Motility and Cell Elongation.Cells · 2020Review
- Mechanobiological Feedback in Pulmonary Vascular Disease.Frontiers in physiology · 2018Review
- Morphology regulation in vascular endothelial cells.Inflammation and regeneration · 2018Review
- Mechanotransmission in endothelial cells subjected to oscillatory and multi-directional shear flow.Journal of the Royal Society, Interface · 2017Article
- Biophysical Tools to Study Cellular Mechanotransduction.Bioengineering (Basel, Switzerland) · 2017Review
- Article
- Biomimetic channel modeling local vascular dynamics of pro-inflammatory endothelial changes.Biomicrofluidics · 2016Article
- Article
- Isotropic actomyosin dynamics promote organization of the apical cell cortex in epithelial cells.The Journal of cell biology · 2014Article
- Shear-induced force transmission in a multicomponent, multicell model of the endothelium.Journal of the Royal Society, Interface · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluid shear stress is the mechanical force generated by the blood flow which is applied over the apical surface of endothelial cells in situ. The findings of a recent study suggest that stress fibers and its associated focal adhesions play roles in mechano-signal transduction mechanism. Stress fibers are present along the apical and the basal portion of the endothelial cells. Endothelial cells respond to fluid shear stress and change their morphological characteristics in both their cell shape and cytoskeletal organization. Atherosclerosis is a common disease of the arteries and it occurs in areas around the branching site of blood vessels where the cells are exposed to low fluid shear stress. The organization of stress fibers and focal adhesions are strongly influenced by shear stress, and therefore the generation of atherosclerotic lesions seem to be associated with the cytoskeletal components of endothelial cells. This review describes the possible role of the cytoskeleton as a mechano-transducer in endothelial cells in situ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.