ArticleEnvironmental health perspectives2009
Mechanisms of inhaled fine particulate air pollution-induced arterial blood pressure changes.
Article in Environmental health perspectives, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Effects of PM2.5 Reduction Interventions on Cardiovascular Indicators: A Meta-analysis.Cardiovascular toxicology · 2025Pooled it
- A systematic review of cardiovascular responses associated with ambient black carbon and fine particulate matter.Environment international · 2019Pooled it
- Gene-air pollution interaction and cardiovascular disease: a review.Progress in cardiovascular diseasesPooled it
- Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans.Hypertension (Dallas, Tex. : 1979) · 2009Trial
- Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozone.Environmental health perspectives · 2009Trial
- The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension.Cardiovascular research · 2026Review
- Article
- Adrenergic receptor subtypes differentially influence acrolein-induced ventilatory, vascular leakage, and inflammatory responses.Toxicology and applied pharmacology · 2025Article
- Lung cell toxicological effects of 3D printer aerosolized filament byproducts.Environmental science and pollution research international · 2025Article
- Disentangling impacts of multiple pollutants on acute cardiovascular events in New York city: A case-crossover analysis.Environmental research · 2024Article
- Influence of Air Pollution Exposures on Cardiometabolic Risk Factors: a Review.Current environmental health reports · 2023Review
- Article
- A self-controlled approach to survival analysis, with application to air pollution and mortality.Environment international · 2021Article
- Social Susceptibility to Multiple Air Pollutants in Cardiovascular Disease.Research report (Health Effects Institute) · 2021Article
- Particulate matter air pollutants and cardiovascular disease: Strategies for intervention.Pharmacology & therapeutics · 2021Review
- Adrenergic and Glucocorticoid Receptors in the Pulmonary Health Effects of Air Pollution.Toxics · 2021Review
- Hypertension in Low- and Middle-Income Countries.Circulation research · 2021Review
- Peat smoke inhalation alters blood pressure, baroreflex sensitivity, and cardiac arrhythmia risk in rats.Journal of toxicology and environmental health. Part A · 2020Article
- Exposure to urban particulate matter and its association with human health risks.Environmental science and pollution research international · 2020Review
- Associations between long-term exposure to air pollution and blood pressure and effect modifications by behavioral factors.Environmental research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundEpidemiologic studies suggest a positive association between fine particulate matter and arterial blood pressure, but the results have been inconsistent.
objectivesWe investigated the effect of ambient particles on systemic hemodynamics during a 5-hr exposure to concentrated ambient air particles (CAPs) or filtered air (FA) in conscious canines.
methodsThirteen dogs were repeatedly exposed via permanent tracheostomy to CAPs (358.1+/-306.7 microg/m3, mean+/-SD) or FA in a crossover protocol (55 CAPs days, 63 FA days). Femoral artery blood pressure was monitored continuously via implanted telemetry devices. We measured baroreceptor reflex sensitivity before and after exposure in a subset of these experiments (n=10 dogs, 19 CAPs days, 20 FA days). In additional experiments, we administered alpha-adrenergic blockade before exposure (n=8 dogs, 16 CAPs days, 15 FA days). Blood pressure, heart rate, rate-pressure product, and baroreceptor reflex sensitivity responses were compared using linear mixed-effects models.
resultsCAPs exposure increased systolic blood pressure (2.7+/-1.0 mmHg, p=0.006), diastolic blood pressure (4.1+/-0.8 mmHg; p<0.001), mean arterial pressure (3.7+/-0.8 mmHg; p<0.001), heart rate (1.6+/-0.5 bpm; p<0.001), and rate-pressure product (539+/-110 bpm x mmHg; p<0.001), and decreased pulse pressure (-1.7+/-0.7 mmHg, p=0.02). These changes were accompanied by a 20+/-6 msec/mmHg (p=0.005) increase in baroreceptor reflex sensitivity after CAPs versus FA. After alpha-adrenergic blockade, responses to CAPs and FA no longer differed significantly.
conclusionsControlled exposure to ambient particles elevates arterial blood pressure. Increased peripheral vascular resistance may mediate these changes, whereas increased baroreceptor reflex sensitivity may compensate for particle-induced alterations in blood pressure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.