ArticleNeuropsychiatric disease and treatment2008
An update on the toxicity of Abeta in Alzheimer's disease.
Article in Neuropsychiatric disease and treatment, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Human amylin is a potent antimicrobial peptide that exhibits antimicrobial synergism with the amyloid beta protein.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Genetic Phenotypes of Alzheimer's Disease: Mechanisms and Potential Therapy.Phenomics (Cham, Switzerland) · 2023Review
- Receptors for Advanced Glycation End Products (RAGE): Promising Targets Aiming at the Treatment of Neurodegenerative Conditions.Current neuropharmacology · 2023Review
- Cannabinoids for Agitation in Alzheimer's Disease.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Review
- TREM2 function impedes tau seeding in neuritic plaques.Nature neuroscience · 2019Article
- Review
- The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review.Frontiers in aging neuroscience · 2019Review
- PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy.BioMed research international · 2015Article
- Altered synaptic structure in the hippocampus in a mouse model of Alzheimer's disease with soluble amyloid-β oligomers and no plaque pathology.Molecular neurodegeneration · 2014Article
- PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Preventing expression of the nicotinic receptor subunit α7 in SH-SY5Y cells with interference RNA indicates that this receptor may protect against the neurotoxicity of Aβ.Neurochemical research · 2013Article
- Lessons from two prevalent amyloidoses-what amylin and Aβ have in common.Frontiers in aging neuroscience · 2013Article
- Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β.Journal of molecular neuroscience : MN · 2012Article
- Alzheimer's disease models and functional genomics-How many needles are there in the haystack?Frontiers in physiology · 2012Article
- MicroRNAs in Neurotoxicity.Journal of toxicology · 2012Article
- Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol.PloS one · 2011Article
- Article
- Article
- Critical appraisal of the long-term impact of memantine in treatment of moderate to severe Alzheimer's disease.Neuropsychiatric disease and treatment · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease is characterized histopathologically by deposition of insoluble forms of the peptide Abeta and the protein tau in brain. Abeta is the principal component of amyloid plaques and tau of neurofibrillary tangles. Familial cases of AD are associated with causal mutations in the gene encoding the amyloid precursor protein, APP, from which the amyloidogenic Abeta peptide is derived, and this supports a role for Abeta in disease. Abeta can promote tau pathology and at the same time its toxicity is also tau-dependent. Abeta can adopt different conformations including soluble oligomers and insoluble fibrillar species present in plaques. We discuss which of these conformations exert toxicity, highlight molecular pathways involved and discuss what has been learned by applying functional genomics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.