ArticleInternational journal of nanomedicine2008
Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts.
Article in International journal of nanomedicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 232 citations in OpenAlex.
- Food-grade titanium dioxide and zinc oxide nanoparticles induce toxicity and cardiac damage after oral exposure in rats.Particle and fibre toxicology · 2023Article
- Effects of Zinc Oxide Nanoparticle Exposure on Human Glial Cells and Zebrafish Embryos.International journal of molecular sciences · 2023Article
- Human and environmental impacts of nanoparticles: a scoping review of the current literature.BMC public health · 2023Article
- Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells.International journal of molecular sciences · 2022Article
- TiOInternational journal of molecular sciences · 2022Review
- Protective Impact of Edaravone Against ZnO NPs-induced Oxidative Stress in the Human Neuroblastoma SH-SY5Y Cell Line.Cellular and molecular neurobiology · 2022Article
- Tungsten disulfide nanotubes enhance flow-induced crystallization and radio-opacity of polylactide without adversely affecting in vitro toxicity.Acta biomaterialia · 2022Article
- Apigenin exerts chemopreventive effects on lung injury induced by SiOJournal of natural medicines · 2022Article
- Functionalized Titanium Nanoparticles Induce Oxidative Stress and Cell Death in Human Skin Cells.International journal of nanomedicine · 2022Article
- Titanium Dioxide, but Not Zinc Oxide, Nanoparticles Cause Severe Transcriptomic Alterations in T98G Human Glioblastoma Cells.International journal of molecular sciences · 2021Article
- The Influence of ZnO Oxide Layer on the Physicochemical Behavior of Ti6Al4V Titanium Alloy.Materials (Basel, Switzerland) · 2021Article
- In vitro Investigation of the Antimicrobial Activity of Mouth Washes Incorporating Zein-Coated Magnesium Oxide Nanoparticles.Clinical, cosmetic and investigational dentistry · 2021Article
- Green Synthesis of MgPolymers · 2020Article
- Mechanoregulation of titanium dioxide nanoparticles in cancer therapy.Materials science & engineering. C, Materials for biological applications · 2020Review
- Particle-size dependent bactericidal activity of magnesium oxide against Xanthomonas perforans and bacterial spot of tomato.Scientific reports · 2019Article
- Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use.Materials (Basel, Switzerland) · 2019Review
- Incorporation ofNanomaterials (Basel, Switzerland) · 2019Article
- Elevated Systemic L-Kynurenine/L-Tryptophan Ratio and Increased IL-1 Beta and Chemokine (CX3CL1, MCP-1) Proinflammatory Mediators in Patients with Long-Term Titanium Dental Implants.Journal of clinical medicine · 2019Article
- Increased Systemic Malondialdehyde Levels and Decreased Mo/Co, Co/FeJournal of clinical medicine · 2019Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The use of titanium dioxide (TiO(2)) in various industrial applications (eg, production of paper, plastics, cosmetics, and paints) has been expanding thereby increasing the occupational and other environmental exposure of these nanoparticles to humans and other species. However, the health effects of exposure to TiO(2) nanoparticles have not been systematically assessed even though recent studies suggest that such exposure induces inflammatory responses in lung tissue and cells. Because the effects of such nanoparticles on human neural cells are unknown, we have determined the putative cytotoxic effects of these nanoparticles on human astrocytes-like astrocytoma U87 cells and compared their effects on normal human fibroblasts. We found that TiO(2) micro- and nanoparticles induced cell death on both human cell types in a concentration-related manner. We further noted that zinc oxide (ZnO) nanoparticles were the most effective, TiO(2) nanoparticles the second most effective, and magnesium oxide (MgO) nanoparticles the least effective in inducing cell death in U87 cells. The cell death mechanisms underlying the effects of TiO(2) micro- and nanoparticles on U87 cells include apoptosis, necrosis, and possibly apoptosis-like and necrosis-like cell death types. Thus, our findings may have toxicological and other pathophysiological implications on exposure of humans and other mammalian species to metallic oxide nanoparticles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.