ArticlePloS one2009
The MHC gene region of murine hosts influences the differential tissue tropism of infecting Trypanosoma cruzi strains.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-19.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Differential tissue distribution of discrete typing units after drug combination therapy in experimentalParasitology · 2021Article
- Host Genetics Background Influence in the IntragastricFrontiers in immunology · 2020Article
- Cardiomyocyte oxidants production may signal to T. cruzi intracellular development.PLoS neglected tropical diseases · 2017Article
- Increased hepatic Th2 and Treg subsets are associated with biliary fibrosis in different strains of mice caused by Clonorchis sinensis.PloS one · 2017Article
- Domestic Pig (Sus scrofa) as an Animal Model for Experimental Trypanosoma cruzi Infection.The American journal of tropical medicine and hygiene · 2016Article
- Aptamer-based detection of disease biomarkers in mouse models for chagas drug discovery.PLoS neglected tropical diseases · 2015Article
- Immunoregulatory networks in human Chagas disease.Parasite immunology · 2014Review
- A genome-wide analysis of genetic diversity in Trypanosoma cruzi intergenic regions.PLoS neglected tropical diseases · 2014Article
- Trypanosomes genetic diversity, polyparasitism and the population decline of the critically endangered Australian marsupial, the brush tailed bettong or woylie (Bettongia penicillata).International journal for parasitology. Parasites and wildlife · 2013Article
- LSSP-PCR of Trypanosoma cruzi: how the single primer sequence affects the kDNA signature.BMC research notes · 2013Article
- The MASP family of Trypanosoma cruzi: changes in gene expression and antigenic profile during the acute phase of experimental infection.PLoS neglected tropical diseases · 2012Article
- Protective human leucocyte antigen haplotype, HLA-DRB1*01-B*14, against chronic Chagas disease in Bolivia.PLoS neglected tropical diseases · 2012Article
- Regulatory T cells phenotype in different clinical forms of Chagas' disease.PLoS neglected tropical diseases · 2011Review
- Molecular mechanisms of host cell invasion by Trypanosoma cruzi.Experimental parasitology · 2010Review
- Coinfection with different Trypanosoma cruzi strains interferes with the host immune response to infection.PLoS neglected tropical diseases · 2010Article
- Lineage analysis of circulating Trypanosoma cruzi parasites and their association with clinical forms of Chagas disease in Bolivia.PLoS neglected tropical diseases · 2010Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously demonstrated that both parasite genetic variability and host genetic background were important in determining the differential tissue distribution of the Col1.7G2 and JG T. cruzi monoclonal strains after artificial infections in mice. We observed that the JG strain was most prevalent in hearts of mouse lineages with the MHC haplotype H-2(d) (BALB/c and DBA2), while Col1.7G2 was predominant in hearts from C57BL/6 mice, which have the H-2(b) haplotype. To assess whether the MHC gene region indeed influenced tissue tropism of T. cruzi, we used the same two parasite strains to infect C57BL/6 (H-2(b)) and C57BLKS/J (H-2(d)) mice; the latter strain results from the introgression of DBA2 MHC region into the C57BL/6 background. We also performed ex vivo infections of cardiac explants from four congenic mice lineages with the H-2(b) and H-2(d) haplotypes arranged in two different genetic backgrounds: C57BLKS/J (H-2(d)) versus C57BL/6 (H-2(b)) and BALB/c (H-2(d)) versus BALB/B10-H2(b) (H-2(b)). In agreement with our former observations, Col1.7G2 was predominant in hearts from C57BL/6 mice (H-2(b)), but we observed a clear predominance of the JG strain in hearts from C57BLKS/J animals (H-2(d)). In the ex vivo experiments Col1.7G2 also prevailed in explants from H-2(b) animals while no predominance of any of the strains was observed in H-2(d) mice explants, regardless of the genetic background. These observations clearly demonstrate that the MHC region influences the differential tissue distribution pattern of infecting T. cruzi strains, which by its turn may be in a human infection the determinant for the clinical forms of the Chagas disease.
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