ReviewMolecular therapy : the journal of the American Society of Gene Therapy2009
Upping the ante: recent advances in direct reprogramming.
Review in Molecular therapy : the journal of the American Society of Gene Therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Attenuated Innate Immunity in Embryonic Stem Cells and Its Implications in Developmental Biology and Regenerative Medicine.Stem cells (Dayton, Ohio) · 2015Review
- Induced Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Neurodegenerative Diseases.Molecular neurobiology · 2015Review
- Software-aided automatic laser optoporation and transfection of cells.Scientific reports · 2015Article
- Cell sources, liver support systems and liver tissue engineering: alternatives to liver transplantation.International journal of stem cells · 2015Review
- Development of stem cell-based therapy for Parkinson's disease.Translational neurodegeneration · 2015Article
- Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis.Cancer medicine · 2014Article
- Mouse embryonic stem cells have underdeveloped antiviral mechanisms that can be exploited for the development of mRNA-mediated gene expression strategy.Stem cells and development · 2014Article
- A Comparative View on Human Somatic Cell Sources for iPSC Generation.Stem cells international · 2014Review
- Transitions between epithelial and mesenchymal states during cell fate conversions.Protein & cell · 2014Review
- Plucked human hair shafts and biomolecular medical research.TheScientificWorldJournal · 2013Review
- Reprogramming cancer cells: back to the future.Oncogene · 2013Article
- Induced pluripotent stem cells as a tool for gaining new insights into Fanconi anemia.Cell cycle (Georgetown, Tex.) · 2012Article
- Article
- Human periodontal ligament fibroblasts are the optimal cell source for induced pluripotent stem cells.Histochemistry and cell biology · 2012Article
- Modeling hepatitis C virus infection using human induced pluripotent stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Generation of human-induced pluripotent stem cells by a nonintegrating RNA Sendai virus vector in feeder-free or xeno-free conditions.Stem cells international · 2012Article
- Article
- Cell- and gene-based therapeutic approaches for neurological deficits in mucopolysaccharidoses.Current pharmaceutical biotechnology · 2011Review
- Derivation of human induced pluripotent stem cells for cardiovascular disease modeling.Circulation research · 2011Review
- Lineage conversion of murine extraembryonic trophoblast stem cells to pluripotent stem cells.Molecular and cellular biology · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The concept of reversing the characteristics of differentiated tissues to pluripotency through reprogramming was introduced over 50 years ago in the first somatic cell nuclear transfer (SCNT) experiments. More recently, direct reprogramming of differentiated somatic cells by gene transfer of a small number of defined transcription factors has been shown to yield cells that are indistinguishable from inner cell mass-derived embryonic stem (ES) cells. These cells, termed induced pluripotent stem (iPS) cells, offer exciting possibilities for studying mechanism of pluripotency, establishing models for disease-specific investigations, and enabling future applications in regenerative medicine. In this review, we discuss the basic foundation of reestablishing pluripotency and recent progress toward enhancing the efficiency and safety of the process through optimization of the reprogramming factor combination, identification of small molecules that augment efficiency, and assessment of distinct target cells in reprogramming efficiency. We also highlight recent advances that eliminate stable genetic modification from the reprogramming process, and summarize preclinical models that provide proof-of-concept for ES/iPS cell-based regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.