Evidence map›Paper›PMID 19337127›Full record

ReviewCurrent opinion in otolaryngology & head and neck surgery2009

Treatment for spasmodic dysphonia: limitations of current approaches.

Christy L Ludlow

Open access · greenAbstract readComparative StudyReview
In one paragraph

Review in Current opinion in otolaryngology & head and neck surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 81 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Laryngeal dystonia: a comprehensive review of aetiology, clinical presentation, diagnosis, and treatment approaches.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Review
  4. Article
  5. Spasmodic dysphonia: the need for a combined neurological and phoniatric approach.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Article
  6. Ultrasound-guided injection into the lateral crico-arytenoid muscle: a pilot study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  7. Review
  8. Impact of Vocal Effort on Respiratory and Articulatory Kinematics.Journal of speech, language, and hearing research : JSLHR · 2022
    Article
  9. Review
  10. Review
  11. Article
  12. Atypical somatosensory-motor cortical response during vowel vocalization in spasmodic dysphonia.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019
    Article
  13. Article
  14. Review
  15. Article
  16. Hoarseness-causes and treatments.Deutsches Arzteblatt international · 2015
    Review
  17. Diagnosis and treatment of dystonia.Neurologic clinics · 2015
    Review
  18. Article
  19. The focal dystonias: current views and challenges for future research.Movement disorders : official journal of the Movement Disorder Society · 2013
    Review
  20. Current and future medical treatment in primary dystonia.Therapeutic advances in neurological disorders · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Christy L LudlowLaryngeal and Speech Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1416, Bethesda, MD 20892-1416, USA. ludlowc@ninds.nih.gov
National Institutes of Health · US

Funding

The Bases Of Normal And Disordered Laryngeal And Speech SystemsZIANS002980 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LUDLOW, CHRISTY LESLIE · 2009 to 2009
$4.3M
THE BASES OF NORMAL AND DISORDERED LARYNGEAL AND SPEECH SYSTEMSZ01NS002980 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI LUDLOW, CHRISTY LESLIE · 1999 to 2008
$3.5M
Development of Novel Methods for Intervention in Chronic DysphagiaZIANS003020 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LUDLOW, CHRISTY LESLIE · 2009 to 2009
$2.2M
Intramural NIH HHS Z01 NS002980
6 · The paper itself

Abstract

purpose of reviewAlthough botulinum toxin injection is the gold standard for treatment of spasmodic dysphonia, surgical approaches aimed at providing long-term symptom control have been advancing over recent years. RECENT

findingsWhen surgical approaches provide greater long-term benefits to symptom control, they also increase the initial period of side effects of breathiness and swallowing difficulties. Recent analyses of quality-of-life questionnaires in patients undergoing regular injections of botulinum toxin demonstrate that a large proportion of patients have limited relief for relatively short periods due to early breathiness and loss-of-benefit before reinjection. SUMMARY: Most medical and surgical approaches to the treatment of spasmodic dysphonia have been aimed at denervation of the laryngeal muscles to block symptom expression in the voice, and have both adverse effects as well as treatment benefits. Research is needed to identify the central neuropathophysiology responsible for the laryngeal muscle spasms in order target treatment towards the central neurological abnormality responsible for producing symptoms.

Indexed as

Botulinum Toxins, Type ADysphoniaHumansInjections, IntramuscularLaryngeal MusclesMicrosurgeryMuscle DenervationOutcome and Process Assessment, Health CareRecurrent Laryngeal NerveBotulinum Toxins, Type A

Identifiers

PMID19337127
PMCPMC2763389
OpenAlexW1989533854

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.