ArticleEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)2009
CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations.
Article in European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 6 of them syntheses that pooled it.
What it found
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Who cites it
32 citing papers in PubMed, 6 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Toll-like receptor 9 (-1237 T/C, -1486 T/C) and the risk of gastric cancer: a meta-analysis of genetic association studies.BMC cancer · 2023Pooled it
- Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis.Frontiers in genetics · 2023Pooled it
- The association between CD14-260C/T polymorphism and malignant tumor risk: a meta-analysis of 5,603 participants.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Pooled it
- The role of TLR2, TLR4 and CD14 genetic polymorphisms in gastric carcinogenesis: a case-control study and meta-analysis.PloS one · 2013Pooled it
- Pooled it
- Innate immunity - the hallmark ofWorld journal of clinical cases · 2021Article
- Association of polymorphisms in TP53 and the promoter region of IL10 with gastric cancer in a Kazakh population.Bosnian journal of basic medical sciences · 2020Article
- Review
- Polymorphisms ofTranslational cancer research · 2020Article
- The Relationship between Toll-like Receptors andJournal of immunology research · 2019Review
- Toll-like receptor 6 expression, sequence variants, and their association with colorectal cancer risk.Journal of Cancer · 2019Article
- Toll-like receptor-9 in hypoxic nasopharyngeal carcinoma cells and its correlation with cell proliferation and apoptosis.Oncology letters · 2017Article
- Toll-like receptors-2 and -9 (TLR2 and TLR9) gene polymorphism in patients with type 2 diabetes and diabetic foot.Medicine · 2017Observational
- Association betweenOncoTargets and therapy · 2017Article
- Association between CD14 SNP -159 C/T and gastric cancer: an independent case-control study and an updated meta-analysis.OncoTargets and therapy · 2016Article
- To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases.World journal of gastroenterology · 2015Review
- Novel role of toll-like receptors in Helicobacter pylori - induced gastric malignancy.World journal of gastroenterology · 2014Review
- Polymorphisms of Toll-like receptor 9 are associated with nasopharyngeal carcinoma susceptibility.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Toll-like receptors in esophageal cancer.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
Host genetic factors play an important role in modifying the risk of human disease, including cancers of the upper gastrointestinal tract, with increasing interest in Toll-like receptor (TLR) signaling and the impact of genetic polymorphisms in these systems. The CD14-159C/T and the TLR9-1237T/C promoter polymorphisms have previously been shown to be associated with various inflammatory conditions including Helicobacter pylori-induced gastritis in Caucasian populations. In this study, we assessed the association of these two functional single nucleotide polymorphisms with gastric cancer in two independent Caucasian population-based case-control studies of upper gastrointestinal tract cancer, initially in 312 noncardia gastric carcinoma cases and 419 controls and then in 184 noncardia gastric carcinomas, 123 cardia carcinomas, 159 esophageal cancers, and 211 frequency-matched controls. Odds ratios were computed from logistic models and adjusted for potential confounding factors. No significant association was found between the CD14-159C/T and the TLR9-1237T/C promoter polymorphisms and increased risk of gastric cancer. Neither single nucleotide polymorphism has been assessed in a Caucasian gastric cancer case-control study before; although the CD14-159C/T polymorphism has been reported to show no apparent association with H. pylori-related gastric malignancy in a Taiwanese Chinese population. In conclusion, although our earlier preliminary studies suggested that the CD14-159C/T and the TLR9-1237T/C promoter polymorphisms increase the risk of precancerous outcomes, they do not seem to increase the risk of gastric cancer itself. This discrepancy merits further examination.
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