ArticlePhysiological genomics2009
Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling.
Article in Physiological genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
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- The methylation landscape and its role in domestication and gene regulation in the chicken.Nature ecology & evolution · 2020Article
- Intra-Individual Behavioural Variability: A Trait under Genetic Control.International journal of molecular sciences · 2020Article
- Genomic resources for dissecting the role of non-protein coding variation in gene-environment interactions.Toxicology · 2020Review
- Genetic Dissection of Femoral and Tibial Microarchitecture.JBMR plus · 2019Article
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- Genetic Dissection of a QTL Affecting Bone Geometry.G3 (Bethesda, Md.) · 2017Article
- Discovering Single Nucleotide Polymorphisms Regulating Human Gene Expression Using Allele Specific Expression from RNA-seq Data.Genetics · 2016Article
- Identification of common regulators of genes in co-expression networks affecting muscle and meat properties.PloS one · 2015Article
- The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.The Journal of clinical investigation · 2014Article
- Elucidating molecular networks that either affect or respond to plasma cortisol concentration in target tissues of liver and muscle.Genetics · 2012Article
- Systems genetic analysis of osteoblast-lineage cells.PLoS genetics · 2012Article
- Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice.Journal of lipid research · 2011Article
- Genome-wide gene expression regulation as a function of genotype and age in C. elegans.Genome research · 2010Article
- Genetic resistance to diet-induced obesity in chromosome substitution strains of mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Using transcriptome profiling to characterize QTL regions on chicken chromosome 5.BMC genomics · 2009Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
HG.CAST-(D9Mit249-D9Mit133) (HG9) congenic mice are homozygous for CAST/EiJ chromosome (Chr) 9 alleles from approximately 9 to 84 Mbp on a C57BL6/J-hg/hg (HG) background. This region contains the carcass fat in high growth mice (Carfhg2) quantitative trait locus (QTL), and while its obesity-promoting effects have been confirmed in HG9 mice, its underlying genetic basis remains elusive. To refine the location of Carfhg2, we preformed a linkage analysis in two congenic F2 intercrosses and progeny-tested a recombinant F2 male. These analyses narrowed Carfhg2 to between 33.0 and 40.8 Mbp on Chr 9. To identify candidate genes we measured the expression of 44 transcripts surrounding the Carfhg2 peak in adipose, brain, liver, and muscle tissues from F2 mice using Biomark 48.48 Dynamic Arrays. In total, 68% (30 of the 44) of genes were regulated by a significant expression QTL (eQTL) in at least one tissue. To prioritize genes with eQTL we used Network Edge Orienting, a causality modeling tool. These analyses advance our goal of identifying the molecular basis of Carfhg2.
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