ArticleDevelopment (Cambridge, England)2009
Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 65 citations in OpenAlex.
- Current updates regarding biogenesis, functions and dysregulation of microRNAs in cancer: Innovative approaches for detection using CRISPR/Cas13‑based platforms (Review).International journal of molecular medicine · 2025Review
- Review
- Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs.Stem cell reports · 2023Article
- The multifaceted roles of microRNAs in differentiation.Current opinion in cell biology · 2020Review
- Integrated analysis of differentially expressed microRNAs and mRNAs to screen miRNAs and genes related to reproduction in3 Biotech · 2019Article
- MicroRNAs in Drosophila Cancer Models.Advances in experimental medicine and biology · 2019Review
- Stereotypical architecture of the stem cell niche is spatiotemporally established by miR-125-dependent coordination of Notch and steroid signaling.Development (Cambridge, England) · 2018Article
- Loss ofeLife · 2017Article
- MicroRNA function in Drosophila melanogaster.Seminars in cell & developmental biology · 2017Review
- Tie-mediated signal from apoptotic cells protects stem cells in Drosophila melanogaster.Nature communications · 2015Article
- Regulation of pattern formation and gene amplification during Drosophila oogenesis by the miR-318 microRNA.Genetics · 2015Article
- Co-expressed Cyclin D variants cooperate to regulate proliferation of germline nuclei in a syncytium.Cell cycle (Georgetown, Tex.) · 2015Article
- MicroRNAs influence reproductive responses by females to male sex peptide in Drosophila melanogaster.Genetics · 2014Article
- A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.Oncogene · 2014Article
- Nutritional regulation of stem and progenitor cells in Drosophila.Development (Cambridge, England) · 2013Review
- MicroRNA regulation and role in stem cell maintenance, cardiac differentiation and hypertrophy.Current molecular medicine · 2013Review
- Receptor tyrosine kinases in Drosophila development.Cold Spring Harbor perspectives in biology · 2013Review
- Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates notch-induced tumourigenesis.PLoS biology · 2013Article
- Characterization and comparative profiling of miRNAs in invasive Bemisia tabaci (Gennadius) B and Q.PloS one · 2013Article
- Insect microRNAs: biogenesis, expression profiling and biological functions.Insect biochemistry and molecular biology · 2013Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is important to understand the regulation of stem cell division because defects in this process can cause altered tissue homeostasis or cancer. The cyclin-dependent kinase inhibitor Dacapo (Dap), a p21/p27 homolog, acts downstream of the microRNA (miRNA) pathway to regulate the cell cycle in Drosophila melanogaster germline stem cells (GSCs). Tissue-extrinsic signals, including insulin, also regulate cell division of GSCs. We report that intrinsic and extrinsic regulators intersect in GSC division control; the Insulin receptor (InR) pathway regulates Dap levels through miRNAs, thereby controlling GSC division. Using GFP-dap 3'UTR sensors in vivo, we show that in GSCs the dap 3'UTR is responsive to Dicer-1, an RNA endonuclease III required for miRNA processing. Furthermore, the dap 3'UTR can be directly targeted by miR-7, miR-278 and miR-309 in luciferase assays. Consistent with this, miR-278 and miR-7 mutant GSCs are partially defective in GSC division and show abnormal cell cycle marker expression, respectively. These data suggest that the GSC cell cycle is regulated via the dap 3'UTR by multiple miRNAs. Furthermore, the GFP-dap 3'UTR sensors respond to InR but not to TGF-beta signaling, suggesting that InR signaling utilizes Dap for GSC cell cycle regulation. We further demonstrate that the miRNA-based Dap regulation may act downstream of InR signaling; Dcr-1 and Dap are required for nutrition-dependent cell cycle regulation in GSCs and reduction of dap partially rescues the cell cycle defect of InR-deficient GSCs. These data suggest that miRNA- and Dap-based cell cycle regulation in GSCs can be controlled by InR signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.