ArticleFEBS letters2009
Identification of LTR-specific small non-coding RNA in FeLV infected cells.
Article in FEBS letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Infectious Causes of Neoplasia in the Domestic Cat.Veterinary sciences · 2022Review
- Rapid characterization of feline leukemia virus infective stages by a novel nested recombinase polymerase amplification (RPA) and reverse transcriptase-RPA.Scientific reports · 2021Article
- LOPH: a novel chemotherapeutic protocol for feline high-grade multicentric or mediastinal lymphoma, developed in an area endemic for feline leukemia virus.Journal of feline medicine and surgery · 2021Article
- Article
- Glutathione S-Transferase (GST) Gene Diversity in the Crustacean Calanus finmarchicus--Contributors to Cellular Detoxification.PloS one · 2015Article
- A novel function of RNAs arising from the long terminal repeat of human endogenous retrovirus 9 in cell cycle arrest.Journal of virology · 2013Article
- Clinical aspects of feline retroviruses: a review.Viruses · 2012Review
- Clinical aspects of feline immunodeficiency and feline leukemia virus infection.Veterinary immunology and immunopathology · 2011Review
- Jaagsiekte sheep retrovirus and enzootic nasal tumor virus promoters drive gene expression in all airway epithelial cells of mice but only induce tumors in the alveolar region of the lungs.Journal of virology · 2011Article
- Prevalence of feline leukaemia provirus DNA in feline lymphomas.Journal of feline medicine and surgery · 2010Article
- Antisense transcription in gammaretroviruses as a mechanism of insertional activation of host genes.Journal of virology · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The U3-LTR region of leukemia viruses transactivates cancer-related signaling pathways through the production of a non-coding RNA transcript although the role of this transcript in virus infection remains unknown. In this study we demonstrate for the first time that an long terminal repeat (LTR)-specific small non-coding RNA is produced from a feline leukemia virus (FeLV)-infected feline cell line. RNA cloning identified this as a 104 base transcript that originates from the U3-LTR region. We also demonstrate that in in vitro assays this LTR-RNA transcript activates NF kappaB signaling. Taken together, our findings suggest a possible role for this LTR transcript in FeLV pathogenesis.
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