ArticleBMC veterinary research2009
Immunohistochemical study of PrP(Sc) distribution in neural and extraneural tissues of two cats with feline spongiform encephalopathy.
Article in BMC veterinary research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 19 citations in OpenAlex.
- First Report of Polymorphisms and Genetic Characteristics ofAnimals : an open access journal from MDPI · 2024Article
- Neuropathology of Animal Prion Diseases.Biomolecules · 2021Review
- Article
- Transmission of sheep-bovine spongiform encephalopathy to pigs.Veterinary research · 2016Article
- Lesion profiling and subcellular prion localization of cervid chronic wasting disease in domestic cats.Veterinary pathology · 2015Article
- De novo prion aggregates trigger autophagy in skeletal muscle.Journal of virology · 2014Article
- Genetic predictions of prion disease susceptibility in carnivore species based on variability of the prion gene coding region.PloS one · 2012Article
- Is the presence of abnormal prion protein in the renal glomeruli of feline species presenting with FSE authentic?BMC veterinary research · 2010Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTwo domestic shorthair cats presenting with progressive hind-limb ataxia and increased aggressiveness were necropsied and a post mortem diagnosis of Feline Spongiform Encephalopathy (FSE) was made. A wide spectrum of tissue samples was collected and evaluated histologically and immunohistologically for the presence of PrPSc.
resultsHistopathological examination revealed a diffuse vacuolation of the grey matter neuropil with the following areas being most severely affected: corpus geniculatum medialis, thalamus, gyrus dentatus of the hippocampus, corpus striatum, and deep layers of the cerebral and cerebellar cortex as well as in the brain stem. In addition, a diffuse glial reaction involving astrocytes and microglia and intraneuronal vacuolation in a few neurons in the brain stem was present.Heavy PrPSc immunostaining was detected in brain, retina, optic nerve, pars nervosa of the pituitary gland, trigeminal ganglia and small amounts in the myenteric plexus of the small intestine (duodenum, jejunum) and slightly in the medulla of the adrenal gland.
conclusionThe PrPSc distribution within the brain was consistent with that described in other FSE-affected cats. The pattern of abnormal PrP in the retina corresponded to that found in a captive cheetah with FSE, in sheep with scrapie and was similar to nvCJD in humans.
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