ArticleInternational journal of experimental pathology2009
The lectin KM+ induces corneal epithelial wound healing in rabbits.
Article in International journal of experimental pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Peroxisome proliferator-activated receptor-α affects corneal epithelial wound healing.Molecular vision · 2024Article
- Adjuvant ArtinM favored the host immunity againstImmunotherapy · 2024Article
- Applications of mannose-binding lectins and mannan glycoconjugates in nanomedicine.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2022Review
- Oral wound healing models and emerging regenerative therapies.Translational research : the journal of laboratory and clinical medicine · 2021Review
- Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis.Frontiers in chemistry · 2021Review
- Topical application of lectin Artin M improves wound healing in defects created in the palatal mucosa: an in vivo study in dogs.Odontology · 2020Article
- Article
- Lectins from red algae and their biomedical potential.Journal of applied phycology · 2018Review
- Frutapin, a lectin fromBioscience reports · 2017Article
- Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Recombinant ArtinM activates mast cells.BMC immunology · 2016Article
- Galectin-3 enhances extracellular matrix associations and wound healing in monkey corneal epithelium.Experimental eye research · 2015Article
- Evaluating the Equilibrium Association Constant between ArtinM Lectin and Myeloid Leukemia Cells by Impedimetric and Piezoelectric Label Free Approaches.Biosensors · 2014Article
- Maintenance of the corneal epithelium is carried out by germinative cells of its basal stratum and not by presumed stem cells of the limbus.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- Characterization of isoforms of the lectin isolated from the red algae Bryothamnion seaforthii and its pro-healing effect.Marine drugs · 2012Article
- Characterization and optimization of ArtinM lectin expression in Escherichia coli.BMC biotechnology · 2012Article
- Restoration of the rabbit corneal surface after total epithelial debridement and complete limbal excision.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Effect of the lectin of Bauhinia variegata and its recombinant isoform on surgically induced skin wounds in a murine model.Molecules (Basel, Switzerland) · 2011Article
- The recognition of N-glycans by the lectin ArtinM mediates cell death of a human myeloid leukemia cell line.PloS one · 2011Article
- Autoradiographic study on the regenerative capability of the epithelium lining the center of the cornea after multiple debridements of its peripheral region.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophil influx is essential for corneal regeneration (Gan et al. 1999). KM+, a lectin from Artocarpus integrifolia, induces neutrophil migration (Santos-de-Oliveira et al. 1994). This study aims at investigating a possible effect of KM+ on corneal regeneration in rabbits. A 6.0-mm diameter area of debridement was created on the cornea of both eyes by mechanical scraping. The experimental eyes received drops of KM+ (2.5 microg/ml) every 2 h. The control eyes received buffer. The epithelial wounded areas of the lectin-treated and untreated eyes were stained with fluorescein, photographed and measured. The animals were killed 12 h (group 1, n = 5), 24 h (group 2, n = 10) and 48 h (group 3, n = 5) after the scraping. The corneas were analysed histologically (haematoxylin and eosin and immunostaining for proliferation cell nuclear antigen, p63, vascular endothelial growth factor, c-Met and laminin). No significant differences were found at the epithelial gap between treated and control eyes in the group 1. However, the number of neutrophils in the wounded area was significantly higher in treated eyes in this group. Three control and seven treated eyes were healed completely and only rare neutrophils persisted in the corneal stroma in group 2. No morphological distinction was observed between treated and control eyes in group 3. In treated corneas of group 2, there was an increase in immunostaining of factors involved in corneal healing compared to controls. Thus, topical application of KM+ may facilitate corneal epithelial wound healing in rabbits by means of a mechanism that involves increased influx of neutrophils into the wounded area induced by the lectin.
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Registered trials
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