Evidence map›Paper›PMID 19335072›Full record

Trial reportJournal of periodontology2009

Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors.

P Ortiz, N F Bissada, L Palomo, Y W Han, M S Al-Zahrani, A Panneerselvam, A Askari

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of periodontology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03087240 (Influence of Dental Prophylaxis on Disease Activity of Rheumatoid Arthritis), which is not on this map. Cited by 124 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 10 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03087240 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Influence of Dental Prophylaxis on Disease Activity of Rheumatoid Arthritis

TypeinterventionalSponsorUniversity Hospital HeidelbergRan2017 to 2020Enrolled70ConditionsRheumatoid Arthritis, Periodontitis, Gingivitis, Dental ProphylaxisArmsDental Prophylaxis
3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 10 syntheses or guidelines pooled it, 343 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Review
  20. Review

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

P OrtizDepartment of Periodontics, Case Western Reserve University, Cleveland, OH 44106-4905, USA.
N F Bissada
L Palomo
Y W Han
M S Al-Zahrani
A Panneerselvam
A Askari
Case Western Reserve University · US

Funding

Molecular Mechanism of F. Nucleatum VirulenceR01DE014924 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HAN, YIPING · 2003 to 2013
$3.0M
F. nucleatum in periodontal disease and preterm birthK02DE016102 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI HAN, YIPING · 2006 to 2010
$591k
Sonoporation as a new genetic tool for F. nucleatumR21DE017165 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI HAN, YIPING · 2007 to 2008
$412k
NIDCR NIH HHS K02 DE016102NIDCR NIH HHS R01 DE014924NIDCR NIH HHS R21 DE017165
6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) and periodontitis are common chronic inflammatory conditions. Recent studies showed a beneficial effect of periodontal treatment on the severity of active RA. This study was undertaken to further examine the effect of non-surgical periodontal treatment on the signs and symptoms of RA in patients treated with or without anti-tumor necrosis factor-alpha (anti-TNF-alpha) medications. The effect of anti-TNF-alpha therapy on periodontitis also was assessed.

methodsForty participants diagnosed with moderate/severe RA (under treatment for RA) and severe periodontitis were randomly assigned to receive initial non-surgical periodontal therapy with scaling/root planing and oral hygiene instructions (n = 20) or no periodontal therapy (n = 20). To control RA, all participants had been using disease-modifying anti-rheumatic drugs, and 20 had also been using anti-TNF-alpha before randomization. Probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI), plaque index (PI), RA disease activity score 28 (DAS28), and erythrocyte sedimentation rate (ESR) were measured at baseline and 6 weeks later. Linear mixed models were used to identify significant differences between subjects who received periodontal treatment and those who did not.

resultsPatients receiving periodontal treatment showed a significant decrease in the mean DAS28, ESR (P <0.001), and serum TNF-alpha (P <0.05). There was no statistically significant decrease in these parameters in patients not receiving periodontal treatment. Anti-TNF-alpha therapy resulted in a significant improvement in CAL, PD, BOP, and GI.

conclusionsNon-surgical periodontal therapy had a beneficial effect on the signs and symptoms of RA, regardless of the medications used to treat this condition. Anti-TNF-alpha therapy without periodontal treatment had no significant effect on the periodontal condition.

Indexed as

AdultAgedAged, 80 and overAntirheumatic AgentsArthritis, RheumatoidChronic PeriodontitisDental Plaque IndexDental ScalingFemaleHumansLinear ModelsMaleMiddle AgedPeriodontal IndexRheumatoid FactorSeverity of Illness IndexAntirheumatic AgentsRheumatoid FactorTumor Necrosis Factor-alpha

Identifiers

PMID19335072
PMCPMC2884010
OpenAlexW2136070771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.