ArticleJournal of the American Chemical Society2009
Perturbations of membrane structure by cholesterol and cholesterol derivatives are determined by sterol orientation.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 85 citations in OpenAlex.
- Lipid metabolism in microglia: Emerging mechanisms and therapeutic opportunities for neurodegenerative diseases (Review).International journal of molecular medicine · 2025Review
- Oxysterols Outcompete Cholesterol Binding to the Membrane-Inserted Cytolysin A Pore Complex.The Journal of membrane biology · 2025Article
- The Structure of Oxysterols Determines Their Behavior at Phase Boundaries: Implications for Model Membranes and Structure-Activity Relationships.Advances in experimental medicine and biology · 2024Review
- Closed-loop fluid-fluid immiscibility in binary lipid-sterol membranes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3.Scientific reports · 2023Article
- Microglia and Cholesterol Handling: Implications for Alzheimer's Disease.Biomedicines · 2022Review
- Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins.European journal of pharmacology · 2022Review
- 25-Hydroxycholesterol as a Signaling Molecule of the Nervous System.Biochemistry. Biokhimiia · 2022Review
- 25-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties.International journal of molecular sciences · 2021Article
- Effect of Transmembrane Electric Field on GM1 Containing DMPC-Cholesterol Monolayer: A Computational Study.The Journal of membrane biology · 2020Article
- Glycosyl chains and 25-hydroxycholesterol contribute to the intracellular transport of amyloid beta (Aβ-42) in Jurkat T cells.FEBS open bio · 2017Article
- Hampering Effect of Cholesterol on the Permeation of Reactive Oxygen Species through Phospholipids Bilayer: Possible Explanation for Plasma Cancer Selectivity.Scientific reports · 2017Article
- Studying antibiotic-membrane interactions via X-ray diffraction and fluorescence microscopy.FEBS open bio · 2015Article
- Identification of a cholesterol-binding pocket in inward rectifier K(+) (Kir) channels.Biophysical journal · 2014Article
- Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.Neuropharmacology · 2014Article
- Improved Coarse-Grained Modeling of Cholesterol-Containing Lipid Bilayers.Journal of chemical theory and computation · 2014Article
- Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling.Biochemistry · 2014Article
- Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi.The Journal of biological chemistry · 2014Article
- The structural basis of cholesterol accessibility in membranes.Biophysical journal · 2013Article
- Calculating the Bending Modulus for Multicomponent Lipid Membranes in Different Thermodynamic Phases.Journal of chemical theory and computation · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cholesterol is essential for proper function and regulation of eukaryotic membranes, and significant amounts of metabolic energy are dedicated to controlling cellular cholesterol levels. Oxidation products of cholesterol, the oxysterols, are enzymatically produced molecules that play a major role in mediating cholesterol homeostasis through mechanisms which have not yet been fully elucidated. Certain oxysterols are known to have direct effects on membrane permeability and structure, effects that are strikingly different from that of cholesterol. We use molecular dynamics simulations of these oxysterols in 1-palmitoyl 2-oleoyl phosphatidylcholine (POPC) bilayers to explain the structural origins for the differing effects of cholesterol and 25-hydroxycholesterol on bilayer properties. In particular, we demonstrate that the source for these differing perturbations is the much wider range of molecular orientations accessible to 25-hydroxycholesterol when compared to cholesterol. This study shows that direct membrane perturbation by side-chain oxysterols is significant and suggests that these membrane perturbations may play a role in the oxysterol regulation of cholesterol homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.