Trial reportAnnals of neurology2009
Sympathetic block with botulinum toxin to treat complex regional pain syndrome.
Trial report in Annals of neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00637533 (A Pilot Clinical Trial of Sympathetic Blockade With Botulinum Toxin Type A to Treat Complex Regional Pain Syndrome), which is not on this map. Cited by 47 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Clinical Trial of Sympathetic Blockade With Botulinum Toxin Type A to Treat Complex Regional Pain Syndrome (CRPS): a Randomized, Double-Blind, Controlled, Crossover Trial.
Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- The Use of Botulinum Toxin Injections in Peripheral Neuropathic Pain: A Systematic Review of Efficacy and Safety Outcomes.Pain research & management · 2026Pooled it
- Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews.The Cochrane database of systematic reviews · 2023Pooled it
- Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 5th Edition.Pain medicine (Malden, Mass.) · 2022Guideline
- Local anaesthetic sympathetic blockade for complex regional pain syndrome.The Cochrane database of systematic reviews · 2016Pooled it
- Interventions for treating pain and disability in adults with complex regional pain syndrome.The Cochrane database of systematic reviews · 2013Pooled it
- Thoracic sympathetic block with botulinum toxin A for complex regional pain syndrome: a retrospective case series.Interventional pain medicine · 2026Article
- Review
- Article
- Perineural Administration of Botulinum Toxin for Chronic Pain Management: A Narrative Review.Pain research & management · 2026Review
- Intramuscular Botulinum Toxin for Complex Regional Pain Syndrome: A Narrative Review of Published Cases.Toxins · 2025Review
- 10. Complex regional pain syndrome.Pain practice : the official journal of World Institute of Pain · 2025Review
- Intra- and Postoperative Botulinum Toxin Injection in Postsurgical Pain Management: A Literature Review.Pain research & management · 2025Review
- Comprehensive Mechanisms and Non-Invasive Treatment for Complex Regional Pain Syndrome: A Narrative Review.Journal of pain research · 2025Review
- A brief review of complex regional pain syndrome and current management.Annals of medicine · 2024Review
- Article
- The efficacy of botulinum toxin in neuropathic pain: a systematic review.British journal of pain · 2024Article
- 12. Vascular pain: Ischemic pain in the extremities and Raynaud's syndromePain practice : the official journal of World Institute of Pain · 2024Review
- Efficacy of botulinum toxin injection using the right-sided unilateral retrocrural approach for celiac plexus in a cancer survivor with persistent abdominal pain: a case report.The Journal of international medical research · 2024Article
- Complex Regional Pain Syndrome.Revista brasileira de ortopedia · 2024Article
- Use of Bioelectrical Impedance Analysis to Explore the Effectiveness of Stellate Ganglion Block in Patients with Post-Stroke Complex Regional Pain Syndrome: A Retrospective Pilot Study.Journal of personalized medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Complex regional pain syndrome is a refractory pain condition with few tested therapies. We hypothesized that botulinum toxin A (BTA) would prolong analgesia after sympathetic blocks in patients with complex regional pain syndrome. We compared the duration of standard lumbar sympathetic block (LSB) with bupivacaine to LSB with bupivacaine and BTA in nine patients with refractory complex regional pain syndrome. Median time to analgesic failure was 71 (95% confidence interval, 12-253) days after LSB with BTA compared with fewer than 10 days (95% confidence interval, 0-12) after standard LSB (log-rank, p < 0.02). BTA profoundly prolonged the analgesia from sympathetic block in this preliminary study.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.