ArticleAnnals of neurology2009
Variant Creutzfeldt-Jakob disease in France and the United Kingdom: Evidence for the same agent strain.
Article in Annals of neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Variant Creutzfeldt-Jakob disease surveillance in Spain, 1993-2021.Frontiers in public health · 2026Article
- Prospective 25-year surveillance of prion diseases in France, 1992 to 2016: a slow waning of epidemics and an increase in observed sporadic forms.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Article
- The role of environmental factors on sporadic Creutzfeldt-Jakob disease mortality: evidence from an age-period-cohort analysis.European journal of epidemiology · 2023Article
- Non-human primates in prion diseases.Cell and tissue research · 2023Review
- Variant CJD: Reflections a Quarter of a Century on.Pathogens (Basel, Switzerland) · 2021Review
- The importance of ongoing international surveillance for Creutzfeldt-Jakob disease.Nature reviews. Neurology · 2021Review
- Direct neural transmission of vCJD/BSE in macaque after finger incision.Acta neuropathologica · 2021Article
- Prion protein codon 129 polymorphism in mild cognitive impairment and dementia: the Rotterdam Study.Brain communications · 2020Article
- In vitro Modeling of Prion Strain Tropism.Viruses · 2019Review
- Recent advances in the histo-molecular pathology of human prion disease.Brain pathology (Zurich, Switzerland) · 2019Review
- Region-specific protein misfolding cyclic amplification reproduces brain tropism of prion strains.The Journal of biological chemistry · 2017Article
- Article
- Epidemiological characteristics of human prion diseases.Infectious diseases of poverty · 2016Review
- [Is Parkinson's disease a prion disease?].Revue neurologique · 2015Review
- First demonstration of transmissible spongiform encephalopathy-associated prion protein (PrPTSE) in extracellular vesicles from plasma of mice infected with mouse-adapted variant Creutzfeldt-Jakob disease by in vitro amplification.The Journal of biological chemistry · 2014Article
- Molecular modeling of prion transmission to humans.Viruses · 2014Article
- Review
- Prion propagation and toxicity occur in vitro with two-phase kinetics specific to strain and neuronal type.Journal of virology · 2013Article
- Constant transmission properties of variant Creutzfeldt-Jakob disease in 5 countries.Emerging infectious diseases · 2012Article
- The first report of a patient with probable variant creutzfeldt-jakob disease in Turkey.Dementia and geriatric cognitive disorders extra · 2011Article
Corrections and comments
- Commented on by
Authors and funding
13 authors.
Funding
Abstract
objectiveVariant Creutzfeldt-Jakob disease (vCJD) was first reported in the United Kingdom in 1996. Since then, the majority of cases have been observed in the United Kingdom where there was a major epidemic of bovine spongiform encephalopathy. France was the second country affected. To address the hypothesis of the involvement of a common strain of agent, we have compared clinical, neuropathological, and biochemical data on vCJD patients from both countries.
methodsIn France and the United Kingdom, epidemiological and clinical data were obtained from analysis of medical records and direct interview of the family of the patients using the same standardized questionnaire in both countries. When brain material was available, we performed with similar methods a comparative study of brain lesions and PrP(res) glycoform ratios in both vCJD populations.
resultsClinical data, genetic background, neuropathological finding, and biochemical findings in the 185 patients observed in France (n = 23) and the United Kingdom (n = 162) were similar except for age at death. Currently, blood transfusion is a risk factor identified only in the United Kingdom.
interpretationThe close similarity between the cases of vCJD in France and the United Kingdom supports the hypothesis that a common strain of infectious agent is involved in both countries. The 5-year delay in the peak that we observed in France compared with the United Kingdom fits well with the increase in the importation of beef products to France from the United Kingdom between 1985 and 1995.
Indexed as
Identifiers
19334063What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.