ArticleGenetic epidemiology2009
Case-control association testing in the presence of unknown relationships.
Article in Genetic epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed.
- Multiscale genetic connectivity, kinship, and demographic history of the Antarctic soft coral Alcyonium antarcticum in the Western Antarctic Peninsula.Scientific reports · 2026Article
- Genomics-Driven Monitoring of Fraxinus latifolia (Oregon Ash) to Inform Conservation and EAB-Resistance Breeding.Molecular ecology · 2025Article
- Precise estimation of in-depth relatedness in biobank-scale datasets using deepKin.Cell reports methods · 2025Article
- Germline predisposition in multiple myeloma.iScience · 2025Article
- Article
- Detecting inbreeding depression in structured populations.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Construction of relatedness matrices in autopolyploid populations using low-depth high-throughput sequencing data.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- A novel rare variants association test for binary traits in family-based designs via copulas.Statistical methods in medical research · 2023Article
- Article
- An unbiased kinship estimation method for genetic data analysis.BMC bioinformatics · 2022Article
- Privacy-aware estimation of relatedness in admixed populations.Briefings in bioinformatics · 2022Article
- To Modify or Not to Modify: Allele-Specific Effects of 3'UTR-Journal of the American Heart Association · 2022Article
- Fine-scale population structure and demographic history of British Pakistanis.Nature communications · 2021Article
- Estimating FST and kinship for arbitrary population structures.PLoS genetics · 2021Article
- Historic and modern genomes unveil a domestic introgression gradient in a wild red junglefowl population.Evolutionary applications · 2020Article
- Accounting for Group-Specific Allele Effects and Admixture in Genomic Predictions: Theory and Experimental Evaluation in Maize.Genetics · 2020Article
- Beyond broad strokes: sociocultural insights from the study of ancient genomes.Nature reviews. Genetics · 2020Review
- Improving predictive models for Alzheimer's disease using GWAS data by incorporating misclassified samples modeling.PloS one · 2020Article
- Association score testing for rare variants and binary traits in family data with shared controls.Briefings in bioinformatics · 2019Article
- Human activities and landscape features interact to closely define the distribution and dispersal of an urban commensal.Evolutionary applications · 2018Article
3 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Genome-wide association studies result in inflated false-positive results when unrecognized cryptic relatedness exists. A number of methods have been proposed for testing association between markers and disease with a correction for known pedigree-based relationships. However, in most case-control studies, relationships are generally unknown, yet the design is predicated on the assumption of at least ancestral relatedness among cases. Here, we focus on adjusting cryptic relatedness when the genealogy of the sample is unknown, particularly in the context of samples from isolated populations where cryptic relatedness may be problematic. We estimate cryptic relatedness using maximum-likelihood methods and use a corrected chi(2) test with estimated kinship coefficients for testing in the context of unknown cryptic relatedness. Estimated kinship coefficients characterize precisely the relatedness between truly related people, but are biased for unrelated pairs. The proposed test substantially reduces spurious positive results, producing a uniform null distribution of P-values. Especially with missing pedigree information, estimated kinship coefficients can still be used to correct non-independence among individuals. The corrected test was applied to real data sets from genetic isolates and created a distribution of P-value that was close to uniform. Thus, the proposed test corrects the non-uniform distribution of P-values obtained with the uncorrected test and illustrates the advantage of the approach on real data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.