ReviewCurrent opinion in drug discovery & development2009
Neuroprotective and cardioprotective conopeptides: an emerging class of drug leads.
Review in Current opinion in drug discovery & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
- Conopeptides as Modulators of Pain and Inflammation in Chemotherapy-Induced Peripheral Neuropathy by Targeting α7 and α9 Nicotinic Acetylcholine Receptors.Neurotoxicity research · 2026Review
- Understanding the Pathophysiology of Ischemic Stroke: The Basis of Current Therapies and Opportunity for New Ones.Biomolecules · 2024Review
- Animal Venoms as Potential Source of Anticonvulsants.F1000Research · 2024Review
- Navigating neurological disorders: harnessing the power of natural compounds for innovative therapeutic breakthroughs.EXCLI journal · 2024Review
- Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels.Marine drugs · 2023Review
- Neurotoxins Acting at Synaptic Sites: A Brief Review on Mechanisms and Clinical Applications.Toxins · 2022Review
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- A novel proline-rich M-superfamily conotoxin that can simultaneously affect sodium, potassium and calcium currents.The journal of venomous animals and toxins including tropical diseases · 2021Article
- High-value compounds from the molluscs of marine and estuarine ecosystems as prospective functional food ingredients: An overview.Food research international (Ottawa, Ont.) · 2020Review
- Synthesis, Structure and Biological Activity of CIA and CIB, Two α-Conotoxins from the Predation-Evoked Venom ofToxins · 2018Article
- Conotoxin MVIIA improves cell viability and antioxidant system after spinal cord injury in rats.PloS one · 2018Article
- A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus).Marine drugs · 2017Article
- Recent Advances in Conotoxin Classification by Using Machine Learning Methods.Molecules (Basel, Switzerland) · 2017Review
- Small Packages, Big Returns: Uncovering the Venom Diversity of Small Invertebrate Conoidean Snails.Integrative and comparative biology · 2016Article
- Combinatorial biosynthesis of RiPPs: docking with marine life.Current opinion in chemical biology · 2016Review
- Article
- Molecular Diversity and Gene Evolution of the Venom Arsenal of Terebridae Predatory Marine Snails.Genome biology and evolution · 2015Article
- Article
- Extraction of venom and venom gland microdissections from spiders for proteomic and transcriptomic analyses.Journal of visualized experiments : JoVE · 2014Article
- Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics.Future medicinal chemistry · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The peptides in the venoms of predatory marine snails belonging to the genus Conus ('cone snails') have well-established therapeutic applications for the treatment of pain and epilepsy. This review discusses the neuroprotective and cardioprotective potential of four families of Conus peptides (conopeptides), including omega-conotoxins that target voltage-gated Ca2+ channels, conantokins that target NMDA receptors, mu-conotoxins that target voltage-gated Na+ channels, and kappa- and kappaM-conotoxins that target K+ channels. The diversity of Conus peptides that have already been shown to exhibit neuroprotective/cardioprotective activity suggests that marine snail venoms are a potentially rich source of drug leads with diverse mechanisms.
Indexed as
Identifiers
19333868PMC2878759W1550605202What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.