Evidence map›Paper›PMID 19333748›Full record

SynthesisJournal of autism and developmental disorders2009

Omega-3 fatty acids for autistic spectrum disorder: a systematic review.

Stephen Bent, Kiah Bertoglio, Robert L Hendren

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of autism and developmental disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Omega-3 fatty acids supplementation for autism spectrum disorders (ASD).The Cochrane database of systematic reviews · 2011
    Pooled it
  4. Trial
  5. Internet-based, randomized, controlled trial of omega-3 fatty acids for hyperactivity in autism.Journal of the American Academy of Child and Adolescent Psychiatry · 2014
    Trial
  6. Trial
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Targeting inhibitory cerebellar circuitry to alleviate behavioral deficits in a mouse model for studying idiopathic autism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  18. The Role of Microbiome, Dietary Supplements, and Probiotics in Autism Spectrum Disorder.International journal of environmental research and public health · 2020
    Review
  19. Trim the fat: the role of omega-3 fatty acids in psychopharmacology.Therapeutic advances in psychopharmacology · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephen BentDepartment of Medicine, Osher Center for Integrative Medicine, University of California, San Francisco VAMC, 111-A1 4150 Clement Street, San Francisco, CA 94121, USA. Stephen.Bent@ucsf.edu
Kiah Bertoglio
Robert L Hendren

Funding

Autism Speaks AS2311
6 · The paper itself

Abstract

We conducted a systematic review to determine the safety and efficacy of omega-3 fatty acids for autistic spectrum disorder (ASD). Articles were identified by a search of MEDLINE, EMBASE, and the Cochrane Database using the terms autism or autistic and omega-3 fatty acids. The search identified 143 potential articles and six satisfied all inclusion criteria. One small randomized controlled trial (n = 13) noted non-significant improvements in hyperactivity and stereotypy. The remaining five studies were small (n = 30, 22, 19, 9, and 1) with four reporting improvements in a wide range of outcomes including language and learning skills, parental observations of general health and behavior, a clinician-administered symptom scale, and clinical observations of anxiety. Due to the limitations of evidence from uncontrolled studies and the presence of only one small randomized controlled trial, there is currently insufficient scientific evidence to determine if omega-3 fatty acids are safe or effective for ASD.

Indexed as

Autistic DisorderChildComplementary TherapiesFatty Acids, Omega-3HumansFatty Acids, Omega-3

Identifiers

PMID19333748
PMCPMC2710498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.