ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2009
Hepatic protection by glycyrrhizin and inhibition of iNOS expression in concanavalin A-induced liver injury in mice.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Analysis of the network pharmacology and the structure-activity relationship of glycyrrhizic acid and glycyrrhetinic acid.Frontiers in pharmacology · 2022Article
- Diammonium glycyrrhizinate lipid ligand ameliorates lipopolysaccharide-induced acute lung injury by modulating vascular endothelial barrier function.Experimental and therapeutic medicine · 2021Article
- Exploring the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Glycyrrhizic and Glycyrrhetinic Acids.Mediators of inflammation · 2021Review
- Review of Constituents and Biological Activities of Triterpene Saponins fromMolecules (Basel, Switzerland) · 2020Review
- The Pharmacological Targets and Clinical Evidence of Natural Products With Anti-hepatic Inflammatory Properties.Frontiers in pharmacology · 2018Review
- Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice.Scientific reports · 2017Article
- Mincle Signaling Promotes Con A Hepatitis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Effects of diammonium glycyrrhizinate on random skin flap survival in rats: An experimental study.Biomedical reports · 2016Article
- The constituents of licorice (Biochemistry and biophysics reports · 2015Article
- Liver fibrosis and mechanisms of the protective action of medicinal plants targeting inflammation and the immune response.International journal of inflammation · 2015Review
- Drug-induced liver injury in hospitalized patients with notably elevated alanine aminotransferase.World journal of gastroenterology · 2012Article
- Herbal products: benefits, limits, and applications in chronic liver disease.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats.International journal of molecular sciences · 2011Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designIn this study, the possible protective effect of glycyrrhizin (GL), an active compound derived from licorice root, was examined on T cell-mediated liver injury in mice. MATERIALS AND
methodsMice were subjected to liver injury by intravenous injection of concanavalin A (Con A). They had been treated with GL (i.p.) 30 min before the injection. Liver injury was estimated by measuring serum levels of alanine aminotransaminase (ALT) and aspartate aminotransaminase (AST), and by examining liver sections with hematoxylin-eosin staining. Expression of inducible nitric oxide synthase (iNOS) mRNA and protein in the liver was determined by reverse transcription polymerase chain reaction (RT-PCR) and Western blotting.
resultsSerum transaminases and hepatic iNOS levels increased with time after Con A treatment. Expression of iNOS mRNA in the liver was elevated for up to 8 h, and at 8 h, GL (ED(50): 10.5 mg/kg) suppressed the increases in AST and ALT in response to Con A. An increase in iNOS mRNA expression and protein was inhibited by treatment with GL. Furthermore, GL inhibited cell infiltration and the degeneration of hepatocytes in the liver of Con A-treated mice.
conclusionThe present study suggests that the prevention by GL of Con A-induced hepatitis is due partly to the modulation of hepatic iNOS induction and of degeneration of hepatocytes.
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