ArticleJournal of bone and mineral metabolism2009
Influence of ferutinin on bone metabolism in ovariectomized rats. I: role in preventing osteoporosis.
Article in Journal of bone and mineral metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Osteo-inductive potential of homoeopathy potencies of Asafoetida on multipotent mesenchymal stem cells in vitro.3 Biotech · 2025Article
- Review
- Rutin Improves Bone Histomorphometric Values by Reduction of Osteoclastic Activity in Osteoporosis Mouse Model Induced by Bilateral Ovariectomy.Journal of Korean Neurosurgical Society · 2020Article
- Ferutinin directs dental pulp-derived stem cells towards the osteogenic lineage by epigenetically regulating canonical Wnt signaling.Biochimica et biophysica acta. Molecular basis of disease · 2020Article
- Comparison the Effect of Ferutinin and 17β-Estradiol on Bone Mineralization of Developing Zebrafish (International journal of molecular sciences · 2019Article
- Interaction among Calcium Diet Content, PTH (1-34) Treatment and Balance of Bone Homeostasis in Rat Model: The Trabecular Bone as Keystone.International journal of molecular sciences · 2019Article
- Olive oil exhibits osteoprotection in ovariectomized rats without estrogenic effects.Experimental and therapeutic medicine · 2016Article
- Natural Products from Chinese Medicines with Potential Benefits to Bone Health.Molecules (Basel, Switzerland) · 2016Review
- Mineral and Skeletal Homeostasis Influence the Manner of Bone Loss in Metabolic Osteoporosis due to Calcium-Deprived Diet in Different Sites of Rat Vertebra and Femur.BioMed research international · 2015Article
- Reciprocal regulation of adipocyte and osteoblast differentiation of mesenchymal stem cells by Eupatorium japonicum prevents bone loss and adiposity increase in osteoporotic rats.Journal of medicinal food · 2014Article
- Protective effects of pomegranate seed oil on ovariectomized rats as a model of postmenopausal osteoporosis: A multi-detector computed tomography evaluation.Veterinary research forum : an international quarterly journal · 2014Article
- Therapeutic advantages of treatment of high-dose curcumin in the ovariectomized rat.Journal of Korean Neurosurgical Society · 2013Article
- Effects of different doses of ferutinin on bone formation/resorption in ovariectomized rats.Journal of bone and mineral metabolism · 2012Article
- Histomorphometric analysis of the spine and femur in ovariectomized rats using micro-computed tomographic scan.Journal of Korean Neurosurgical Society · 2012Article
- The Change of Bone Metabolism in Ovariectomized Rats : Analyses of MicroCT Scan and Biochemical Markers of Bone Turnover.Journal of Korean Neurosurgical Society · 2012Article
- Influence of ferutinin on bone metabolism in ovariectomized rats. II: role in recovering osteoporosis.Journal of anatomy · 2010Article
- Osteogenic induction of menstrual blood mesenchymal stem cell by differentAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytoestrogens play a role in maintaining bone mass in the post-menopausal period for their putative function as osteoprotective agents. The aim of the present study was to investigate the influence of Ferutinin, a phytoestrogen found in the plants of Ferula genus, on bone loss in ovariectomized rats. Such an animal model can simulate the various clinical syndromes deriving from osteoporosis. The effect of the daily oral administration of ferutinin to ovariectomized rats (dosed at 2 mg/kg per day for 30 and 60 days) was compared to that of estradiol benzoate (subcutaneously administered at the dose of 1.5 microg/rat twice a week). After the sacrifice, histomorphometrical analyses were performed on trabecular bone of L4-L5 vertebrae and distal femoral metaphysis, as well as on cortical bone of femoral diaphysis; biochemical parameters (bone mineral components and markers) were also evaluated from the rat serum. The histomorphometrical analyses of trabecular and cortical bone from lumbar vertebrae and femur showed that ferutinin has the same antiosteoporotic effect of estradiol benzoate on bone mass, and in some cases is even stronger. This fact suggests that it could prevent osteoporosis caused by severe estrogen deficiency in ovariectomized rats. The possibility of using ferutinin as an alternative to the commonly employed hormonal replacing therapy in post-menopausal women is discussed.
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