ReviewCellular and molecular life sciences : CMLS2009
Estrogen and progesterone receptors: from molecular structures to clinical targets.
Review in Cellular and molecular life sciences : CMLS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 141 citations in OpenAlex.
- Impact of Maternal Euthyroid Autoimmune Thyroiditis on Minipuberty in Female Offspring.Nutrients · 2026Article
- Molecular Mechanisms of Dysregulated LH and FSH Secretion in Human Reproductive Failure.Biomedicines · 2026Review
- Review
- The Clinical Implications of Progesterone in Preeclampsia.Biomolecules · 2025Review
- Diffraction-informed deep learning for molecular-specific holograms of breast cancer cells.APL bioengineering · 2025Article
- Review
- DCAF13 is essential for mouse uterine function and fertility.Cell death discovery · 2025Article
- Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions.Signal transduction and targeted therapy · 2025Review
- Folic acid supplementation alleviates donor cattle's heat stress and improves in vitro embryo production efficiency in summer.Journal of animal science · 2025Article
- The Impact of Gestational Diabetes Mellitus on Minipuberty in Girls.International journal of molecular sciences · 2024Article
- Sperm epigenetics and male infertility: unraveling the molecular puzzle.Human genomics · 2024Review
- A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior.Cell · 2022Article
- Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Ketamine Treatment for Mood Disorders in Women.Frontiers in psychiatry · 2021Review
- LncRNA APTR Promotes Uterine Leiomyoma Cell Proliferation by Targeting ERα to Activate the Wnt/β-Catenin Pathway.Frontiers in oncology · 2021Article
- Sex differences in schizophrenia, bipolar disorder, and post-traumatic stress disorder: Are gonadal hormones the link?British journal of pharmacology · 2019Review
- Novel Selective Estrogen Receptor Modulator Ameliorates Murine Colitis.International journal of molecular sciences · 2019Article
- Expression of phosphorylated estrogen receptor beta is an independent negative prognostic factor for pancreatic ductal adenocarcinoma.Journal of cancer research and clinical oncology · 2018Article
- Human Chorionic Gonadotrophin as a Possible Mediator of Leiomyoma Growth during Pregnancy: Molecular Mechanisms.International journal of molecular sciences · 2017Review
- Estrogen Receptors and Signaling in Fibroids: Role in Pathobiology and Therapeutic Implications.Reproductive sciences (Thousand Oaks, Calif.) · 2017Review
- Multiplexed Electrochemical Immunosensors for Clinical Biomarkers.Sensors (Basel, Switzerland) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research involving estrogen and progesterone receptors (ER and PR) have greatly contributed to our understanding of cell signaling and transcriptional regulation. In addition to the classical ER and PR nuclear actions, new signaling pathways have recently been identified due to ER and PR association with cell membranes and signal transduction proteins. Bio-informatics has unveiled how ER and PR recognize their ligands, selective modulators and co-factors, which has helped to implement them as key targets in the treatment of benign and malignant tumors. Knowledge regarding ER and PR is vast and complex; therefore, this review will focus on their isoforms, signaling pathways, co-activators and co-repressors, which lead to target gene regulation. Moreover it will highlight ER and PR involvement in benign and malignant diseases as well as pharmacological substances influencing cell signaling and provide established and new structural insights into the mechanism of activation and inhibition of these receptors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.