ArticleInternational journal of molecular sciences2009
Developmental toxicity of Ochratoxin A in rat embryo midbrain micromass cultures.
Article in International journal of molecular sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Assessment of Maternal Exposure to Mycotoxins During Pregnancy Through Biomarkers in Fetal and Neonatal Tissues.Toxins · 2025Article
- In vitro and computational approaches to predict developmental toxicity: Integrating PBPK models with cell-based assays.Toxicology and applied pharmacology · 2025Article
- The Neurotoxic Effect of Ochratoxin-A on the Hippocampal Neurogenic Niche of Adult Mouse Brain.Toxins · 2022Article
- Food-Origin Mycotoxin-Induced Neurotoxicity: Intend to Break the Rules of Neuroglia Cells.Oxidative medicine and cellular longevity · 2021Review
- Risk assessment of ochratoxin A in food.EFSA journal. European Food Safety Authority · 2020Article
- Detecting Neurodevelopmental Toxicity of Domoic Acid and Ochratoxin A Using Rat Fetal Neural Stem Cells.Marine drugs · 2019Article
- Article
- Protective effects of compound ammonium glycyrrhizin, L‑arginine, silymarin and glucurolactone against liver damage induced by ochratoxin A in primary chicken hepatocytes.Molecular medicine reports · 2018Article
- Limited Link between Oxidative Stress and Ochratoxin A-Induced Renal Injury in an Acute Toxicity Rat Model.Toxins · 2016Article
- Mycoflora and ochratoxin a control in wheat grain using natural extracts obtained from wine industry by-products.International journal of molecular sciences · 2012Article
- Evaluation of Enamel Matrix Derivative (EMD) Teratogenicity on the Rat Embryo Neural Crest Culture.Iranian journal of pharmaceutical research : IJPR · 2011Article
- Changes in metallothionein level in rat hepatic tissue after administration of natural mouldy wheat.International journal of molecular sciences · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryonic midbrain micromass cultures were exposed for five days to ochratoxin A (OTA) at seven concentrations (ranging from 0.16 to 10 microg/mL). Cell viability was assessed in neutral red uptake test (NRU), and differentiation - by immunoenzymatic determination of structural proteins (beta(III)-tubulin, MAP2, GFAP) expression level as well as by computer image analysis. Dose dependent decrease in cell number and differentiation was observed. Concentration-response curves were analysed and the mean inhibition concentrations (microg/mL) for cytotoxicity (IC(50)) and differentiation (ID(50)) were calculated. There were no significant differences in the sensitivity of neurons in early and late stage of differentiation and astrocytes to the toxic activity of this compound. For all endpoints ID(50) value was very low (< 10 microg/mL) so OTA was classified as a strong teratogen. IC(50)/ ID(50) ratios <2 pointed out that with harmful action of OTA the basic cytotoxicity should be connected.
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