ArticleInternational journal of molecular sciences2009
Genetic exchange of multidrug efflux pumps among two enterobacterial species with distinctive ecological Niches.
Article in International journal of molecular sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- De novo biosynthesis of alpinetin enhanced by directed evolution of 5-O-methyltransferase.Microbial cell factories · 2026Article
- An overview on anti-biofilm properties of quercetin against bacterial pathogens.World journal of microbiology & biotechnology · 2019Review
- The population genetic test Tajima's D identifies genes encoding pathogen-associated molecular patterns and other virulence-related genes in Ralstonia solanacearum.Molecular plant pathology · 2018Article
- Phylogenetic spectrum and analysis of antibacterial activities of leaf extracts from plants of the genus Rhododendron.BMC complementary and alternative medicine · 2015Article
- Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump.MicrobiologyOpen · 2014Article
- Characterization of AcrD, a resistance-nodulation-cell division-type multidrug efflux pump from the fire blight pathogen Erwinia amylovora.BMC microbiology · 2014Article
- Characterization of genes required for the pathogenicity of Pectobacterium carotovorum subsp. carotovorum Pcc21 in Chinese cabbage.Microbiology (Reading, England) · 2013Article
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3 authors.
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Abstract
AcrAB-TolC is the major multidrug efflux system in Enterobacteriaceae recognizing structurally unrelated molecules including antibiotics, dyes, and detergents. Additionally, in Escherichia coli it mediates resistance to bile salts. In the plant pathogen Erwinia amylovora AcrAB-TolC is required for virulence and phytoalexin resistance. Exchange analysis of AcrAB-TolC was conducted by complementing mutants of both species defective in acrB or tolC with alleles from either species. The acrB and tolC mutants exhibited increased susceptibility profiles for 24 different antibiotics. All mutants were complemented with acrAB or tolC, respectively, regardless of the taxonomic origin of the alleles. Importantly, complementation of E. amylovora mutants with respective E. coli genes restored virulence on apple plants. It was concluded that AcrAB and TolC of both species could interact and that these interactions did not yield in altered functions despite the divergent ecological niches, to which E. coli and E. amylovora have adopted.
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