ArticleGenetics2009
Candida glabrata PHO4 is necessary and sufficient for Pho2-independent transcription of phosphate starvation genes.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Genetic Tools in the Nakaseomyces clade for Evolutionary Comparisons of Signal Transduction Pathways.Yeast (Chichester, England) · 2026Article
- Article
- The transcriptional response to environmental alkalization involves both Komagataella phaffii Pho4 transcription factors.Microbial cell factories · 2026Article
- Divergence in a eukaryotic transcription factor's co-TF dependence involves multiple intrinsically disordered regions.Nature communications · 2025Article
- Divergence in a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions.bioRxiv : the preprint server for biology · 2025Article
- Grf10 regulates the response to copper, iron, and phosphate in Candida albicans.G3 (Bethesda, Md.) · 2023Article
- Article
- A transcriptional activator fromFrontiers in microbiology · 2022Article
- Phosphate in Virulence ofJournal of fungi (Basel, Switzerland) · 2020Review
- Review
- Dynamic Changes in Yeast Phosphatase Families Allow for Specialization in Phosphate and Thiamine Starvation.G3 (Bethesda, Md.) · 2018Article
- Phosphate Acquisition and Virulence in Human Fungal Pathogens.Microorganisms · 2017Review
- Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway.eLife · 2017Article
- Core regulatory components of the PHO pathway are conserved in the methylotrophic yeast Hansenula polymorpha.Current genetics · 2016Article
- Partial Decay of Thiamine Signal Transduction Pathway Alters Growth Properties of Candida glabrata.PloS one · 2016Article
- The GRF10 homeobox gene regulates filamentous growth in the human fungal pathogen Candida albicans.FEMS yeast research · 2015Article
- Dissection of the PHO pathway in Schizosaccharomyces pombe using epistasis and the alternate repressor adenine.Current genetics · 2015Article
- Defects in phosphate acquisition and storage influence virulence of Cryptococcus neoformans.Infection and immunity · 2014Article
- Conservation of PHO pathway in ascomycetes and the role of Pho84.Journal of biosciences · 2014Review
- Comparative genomics of emerging pathogens in the Candida glabrata clade.BMC genomics · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparative genomic analyses of Candida glabrata and Saccharomyces cerevisiae suggest many signal transduction pathways are highly conserved. Focusing on the phosphate signal transduction (PHO) pathway of C. glabrata, we demonstrate that components of the pathway are conserved and confirm the role of CgPHO81, CgPHO80, CgPHO4, and CgMSN5 in the PHO pathway through deletion analysis. Unlike S. cerevisiae, C. glabrata shows little dependence on the transcription factor, Pho2, for induction of phosphate-regulated genes during phosphate limitation. We show that the CgPho4 protein is necessary and sufficient for Pho2-independent gene expression; CgPho4 is capable of driving expression of PHO promoters in S. cerevisiae in the absence of ScPHO2. On the basis of the sequences of PHO4 in the hemiascomycetes and complementation analysis, we suggest that Pho2 dependence is a trait only observed in species closely related to S. cerevisiae. Our data are consistent with trans-regulatory changes in the PHO pathway via the transcription factor Pho4 as opposed to cis-regulatory changes (the promoter).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.