ArticleMolecular biology and evolution2009
Origin and ascendancy of a chimeric fusion gene: the beta/delta-globin gene of paenungulate mammals.
Article in Molecular biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Adaptive Changes in Hemoglobin Function in High-Altitude Tibetan Canids Were Derived via Gene Conversion and Introgression.Molecular biology and evolution · 2019Article
- Emergence of a Chimeric Globin Pseudogene and Increased Hemoglobin Oxygen Affinity Underlie the Evolution of Aquatic Specializations in Sirenia.Molecular biology and evolution · 2019Article
- Gene Turnover and Diversification of the α- and β-Globin Gene Families in Sauropsid Vertebrates.Genome biology and evolution · 2018Article
- Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades.Science advances · 2017Article
- Hemoglobin-oxygen affinity in high-altitude vertebrates: is there evidence for an adaptive trend?The Journal of experimental biology · 2016Review
- Gene Duplication and Evolutionary Innovations in Hemoglobin-Oxygen Transport.Physiology (Bethesda, Md.) · 2016Review
- Genetically based low oxygen affinities of felid hemoglobins: lack of biochemical adaptation to high-altitude hypoxia in the snow leopard.The Journal of experimental biology · 2015Article
- Intraspecific polymorphism, interspecific divergence, and the origins of function-altering mutations in deer mouse hemoglobin.Molecular biology and evolution · 2015Article
- Gene turnover in the avian globin gene families and evolutionary changes in hemoglobin isoform expression.Molecular biology and evolution · 2015Article
- Article
- Repeated evolution of chimeric fusion genes in the β-globin gene family of laurasiatherian mammals.Genome biology and evolution · 2014Article
- Gene duplication, genome duplication, and the functional diversification of vertebrate globins.Molecular phylogenetics and evolution · 2013Review
- Whole-genome duplication and the functional diversification of teleost fish hemoglobins.Molecular biology and evolution · 2013Article
- Evolution of hemoglobin and its genes.Cold Spring Harbor perspectives in medicine · 2012Article
- Copy number polymorphism in the α-globin gene cluster of European rabbit (Oryctolagus cuniculus).Heredity · 2012Article
- Chimeric genes as a source of rapid evolution in Drosophila melanogaster.Molecular biology and evolution · 2012Article
- Revealing mammalian evolutionary relationships by comparative analysis of gene clusters.Genome biology and evolution · 2012Article
- Altitudinal variation at duplicated β-globin genes in deer mice: effects of selection, recombination, and gene conversion.Genetics · 2012Article
- In with the old, in with the new: the promiscuity of the duplication process engenders diverse pathways for novel gene creation.International journal of evolutionary biology · 2012Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
The delta-globin gene (HBD) of eutherian mammals exhibits a propensity for recombinational exchange with the closely linked beta-globin gene (HBB) and has been independently converted by the HBB gene in multiple lineages. Here we report the presence of a chimeric beta/delta fusion gene in the African elephant (Loxodonta africana) that was created by unequal crossing-over between misaligned HBD and HBB paralogs. The recombinant chromosome that harbors the beta/delta fusion gene in elephants is structurally similar to the "anti-Lepore" duplication mutant of humans (the reciprocal exchange product of the hemoglobin Lepore deletion mutant). However, the situation in the African elephant is unique in that the chimeric beta/delta fusion gene supplanted the parental HBB gene and is therefore solely responsible for synthesizing the beta-chain subunits of adult hemoglobin. A phylogenetic survey of beta-like globin genes in afrotherian and xenarthran mammals revealed that the origin of the chimeric beta/delta fusion gene and the concomitant inactivation of the HBB gene predated the radiation of "Paenungulata," a clade of afrotherian mammals that includes three orders: Proboscidea (elephants), Sirenia (dugongs and manatees), and Hyracoidea (hyraxes). The reduced fitness of the human Hb Lepore deletion mutant helps to explain why independently derived beta/delta fusion genes (which occur on an anti-Lepore chromosome) have been fixed in a number of mammalian lineages, whereas the reciprocal delta/beta fusion gene (which occurs on a Lepore chromosome) has yet to be documented in any nonhuman mammal. This illustrates how the evolutionary fates of chimeric fusion genes can be strongly influenced by their recombinational mode of origin.
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