ArticleThe Journal of physiology2009
Switching between transient and sustained signalling at the rod bipolar-AII amacrine cell synapse of the mouse retina.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- A hierarchical electrical synaptic circuit mechanism for integrative parallel visual processing in the retina.Neuron · 2026Article
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- A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness.The Journal of general physiology · 2025Article
- Functional maturation of the rod bipolar to AII-amacrine cell ribbon synapse in the mouse retina.Cell reports · 2023Article
- Article
- Multiple Calcium Channel Types with Unique Expression Patterns Mediate Retinal Signaling at Bipolar Cell Ribbon Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Rod bipolar cells dysfunction occurs before ganglion cells loss in excitotoxin-damaged mouse retina.Cell death & disease · 2019Article
- Rapid and coordinated processing of global motion images by local clusters of retinal ganglion cells.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Article
- Postsynaptic Plasticity Triggered by Ca²⁺-Permeable AMPA Receptor Activation in Retinal Amacrine Cells.Neuron · 2016Article
- Visualizing synaptic vesicle turnover and pool refilling driven by calcium nanodomains at presynaptic active zones of ribbon synapses.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Synaptic ribbons influence the size and frequency of miniature-like evoked postsynaptic currents.Neuron · 2013Article
- Paired-pulse plasticity in the strength and latency of light-evoked lateral inhibition to retinal bipolar cell terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The mode of retinal presynaptic inhibition switches with light intensity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Characterization of Trpm1 desensitization in ON bipolar cells and its role in downstream signalling.The Journal of physiology · 2012Article
- Redefining the classification of AMPA-selective ionotropic glutamate receptors.The Journal of physiology · 2012Review
- Carbonic anhydrase-related protein VIII is expressed in rod bipolar cells and alters signaling at the rod bipolar to AII-amacrine cell synapse in the mammalian retina.The European journal of neuroscience · 2011Article
- Ribbon synapses compute temporal contrast and encode luminance in retinal rod bipolar cells.Nature neuroscience · 2011Article
- Trigger features and excitation in the retina.Current opinion in neurobiology · 2011Review
- Grilled RIBEYE stakes a claim for synaptic ribbons.Nature neuroscience · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
At conventional synapses, invasion of an action potential into the presynaptic terminal produces a rapid Ca(2+) influx and ultimately the release of synaptic vesicles. However, retinal rod bipolar cells (RBCs) generally do not produce action potentials, and the rate of depolarization of the axon terminal is instead governed by the rate of rise of the light response, which can be quite slow. Using paired whole-cell recordings, we measured the behaviour of the RBC-AII amacrine cell synapse while simulating light-induced depolarizations either by slowly ramping the RBC voltage or by depolarizing the RBC with the mGluR6 receptor antagonist (R,S)-alpha-cyclopropyl-4-phosphonophenylglycine (CPPG). Both voltage ramps and CPPG evoked slow activation of presynaptic Ca(2+) currents and severely attenuated the early, transient component of the AII EPSC compared with voltage steps. We also found that the duration of the transient component was limited in time, and this limitation could not be explained by vesicle depletion, inhibitory feedback, or proton inhibition. Limiting the duration of the fast transient insures the availability of readily releasable vesicles to support a second, sustained component of release. The mGluR6 pathway modulator cGMP sped the rate of RBC depolarization in response to puffs of CPPG and consequently potentiated the transient component of the EPSC at the expense of the sustained component. We conclude that the rod bipolar cell is capable of both transient and sustained signalling, and modulation of the mGluR6 pathway by cGMP allows the RBC to switch between these two time courses of transmitter release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.