ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2009
Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- A systematic review of genetic mutations in pulmonary arterial hypertension.BMC medical genetics · 2017Pooled it
- Mendelian randomization study of serum uric acid levels and urate-lowering drugs on pulmonary arterial hypertension outcomes.Scientific reports · 2025Article
- Insights into the relationship between serum uric acid and pulmonary hypertension (Review).Molecular medicine reports · 2024Review
- The emerging role of sacubitril/valsartan in pulmonary hypertension with heart failure.Frontiers in cardiovascular medicine · 2023Review
- Common Variation inFrontiers in cardiovascular medicine · 2022Article
- 'There and Back Again'-Forward Genetics and Reverse Phenotyping in Pulmonary Arterial Hypertension.Genes · 2020Review
- Analysis of Association of Angiotensin II Type 1 Receptor Gene A1166C Gene Polymorphism with Essential Hypertension.Indian journal of clinical biochemistry : IJCB · 2018Article
- Pulmonary vascular and ventricular dysfunction in the susceptible patient (2015 Grover Conference series).Pulmonary circulation · 2016Review
- Parallel Selection Revealed by Population Sequencing in Chicken.Genome biology and evolution · 2015Article
- Activation of renin-angiotensin-aldosterone system (RAAS) in the lung of smoking-induced pulmonary arterial hypertension (PAH) rats.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2015Article
- Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.British journal of pharmacology · 2015Article
- Molecular and clinical analysis of TRPC6 and AGTR1 genes in patients with pulmonary arterial hypertension.Orphanet journal of rare diseases · 2015Article
- Interleukin 13- and interleukin 17A-induced pulmonary hypertension phenotype due to inhalation of antigen and fine particles from air pollution.Pulmonary circulation · 2014Article
- Neuroinflammation in pulmonary hypertension: concept, facts, and relevance.Current hypertension reports · 2014Review
- A quantitative trait locus for ascites on chromosome 9 in broiler chicken lines.Poultry science · 2014Article
- Role of notch signal in angiotensin II induced pulmonary vascular remodeling.Translational pediatrics · 2013Article
- TrACEing angiotensin II type 1 to right ventricular hypertrophy: are the "sartans" a viable course to treating pulmonary arterial hypertension?American journal of respiratory and critical care medicine · 2012Article
- Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension.American journal of respiratory and critical care medicine · 2012Article
- Pulmonary arterial hypertension: a comparison between children and adults.The European respiratory journal · 2011Review
- The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension.American journal of respiratory and critical care medicine · 2010Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPulmonary arterial hypertension (PAH) is a rare, lethal disease associated with single gene disorders, connective tissue disease, exposures to anorexigens, and often, idiopathic etiology. Genes can modify the risk of PAH: (1) monogenic disorders associated with PAH are incompletely penetrant, and (2) not all patients with associated conditions at increased risk for PAH develop the disease. The renin angiotensin aldosterone system (RAAS) provides a set of candidate genes that could modulate pulmonary vascular disease similar to its effects on renal and peripheral vasculature.
methodsWe studied 247 patients with PAH, comprising 177 with idiopathic PAH (IPAH), 63 with PAH/connective tissue disease (CTD), and 7 with PAH associated with anorexigens. Patients were genotyped for 5 common polymorphisms in angiotensinogen (AGT), angiotensin-converting enzyme (ACE), cardiac chymase A (CMA1), angiotensin II type 1 receptor (AGTR1), and aldosterone synthase (CYP11B2). Genotypes were tested for associations with age at diagnosis, hemodynamic parameters at diagnosis, and/or response to acute pulmonary vasodilator testing at diagnosis.
resultsAssociations were demonstrated for AGTR1 and age at diagnosis in IPAH (p = 0.005). Homozygotes for the 1166C allele (n = 13) were associated with an age at diagnosis 26 years later than those with A/A (n = 139) or A/C (n = 90) genotypes. No associations were demonstrated for AGT, ACE, CMA1, or CYP11B2.
conclusionsThe 1166C polymorphism in AGTR1 appears to be associated with a later age at diagnosis in IPAH, suggesting that this pathway could be involved in the biologic variability that is known to occur in PAH.
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