ArticleGene2009
The homeodomain protein Cux1 interacts with Grg4 to repress p27 kip1 expression during kidney development.
Article in Gene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- Histone deacetylases and their inhibitors in kidney diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Conceptualizing Epigenetics and the Environmental Landscape of Autism Spectrum Disorders.Genes · 2023Review
- Polycystic kidneys: interaction of notch and renin.Clinical science (London, England : 1979) · 2023Article
- Functioning and mechanisms of PTMs in renal diseases.Frontiers in pharmacology · 2023Review
- Article
- Histone deacetylase 3 (HDAC3) as an important epigenetic regulator of kidney diseases.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study.Clinical epigenetics · 2021Article
- Cux1 regulation of the cyclin kinase inhibitor p27Gene: X · 2019Article
- Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease.Scientific reports · 2018Article
- Cux1 promotes cell proliferation and polycystic kidney disease progression in an ADPKD mouse model.American journal of physiology. Renal physiology · 2017Article
- Regulation of retinoic acid synthetic enzymes by WT1 and HDAC inhibitors in 293 cells.International journal of molecular medicine · 2017Article
- TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway.Oncotarget · 2016Article
- Nhej1 Deficiency Causes Abnormal Development of the Cerebral Cortex.Molecular neurobiology · 2015Article
- The Groucho/Transducin-like enhancer of split protein family in animal development.IUBMB life · 2015Review
- CUX1 modulates polarization of tumor-associated macrophages by antagonizing NF-κB signaling.Oncogene · 2015Article
- CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers.Nature reviews. Cancer · 2014Review
- HDAC inhibitors in kidney development and disease.Pediatric nephrology (Berlin, Germany) · 2013Review
- Transcriptional profiling of HMGB1-induced myocardial repair identifies a key role for Notch signaling.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy.American journal of physiology. Renal physiology · 2013Article
- Histone deacetylase (HDAC) activity is critical for embryonic kidney gene expression, growth, and differentiation.The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The homeodomain protein Cux1 is highly expressed in the nephrogenic zone of the developing kidney where it functions to regulate cell proliferation. Here we show that Cux1 directly interacts with the co-repressor Grg4 (Groucho 4), a known effector of Notch signaling. Promoter reporter based luciferase assays revealed enhanced repression of p27(kip1) promoter activity by Cux1 in the presence of Grg4. Chromatin immunoprecipitation (ChIP) assays demonstrated the direct interaction of Cux1 with p27(kip1) in newborn kidney tissue in vivo. ChIP assays also identified interactions of Cux1, Grg4, HDAC1, and HDAC3 with p27(kip1) at two separate sites in the p27(kip1) promoter. DNAse1 footprinting experiments revealed that Cux1 binds to the p27(kip1) promoter on the sequence containing two Sp1 sites and a CCAAT box approximately 500 bp from the transcriptional start site, and to an AT rich sequence approximately 1.5 kb from the transcriptional start site. Taken together, these results identify Grg4 as an interacting partner for Cux1 and suggest a mechanism of p27(kip1) repression by Cux1 during kidney development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.