ArticleExperimental cell research2009
Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activities.
Article in Experimental cell research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- NovelCold Spring Harbor molecular case studies · 2019Article
- Dual Role of the Alternative Reading Frame ARF Protein in Cancer.Biomolecules · 2019Review
- RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth.The Journal of clinical investigation · 2019Article
- PKC Dependent p14ARF Phosphorylation on Threonine 8 Drives Cell Proliferation.Scientific reports · 2018Article
- The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A.PLoS genetics · 2017Article
- TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification.Molecular and cellular biology · 2015Article
- RABL6A promotes G1-S phase progression and pancreatic neuroendocrine tumor cell proliferation in an Rb1-dependent manner.Cancer research · 2014Article
- The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.Molecular biology of the cell · 2014Article
- Article
- A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction.Autophagy · 2013Article
- Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression.Molecular cell · 2013Article
- RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts.PloS one · 2013Article
- Mimicking p14ARF phosphorylation influences its ability to restrain cell proliferation.PloS one · 2013Article
- NMI mediates transcription-independent ARF regulation in response to cellular stresses.Molecular biology of the cell · 2012Article
- The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis.Molecular cancer research : MCR · 2011Article
- Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The Alternative Reading Frame (ARF) protein suppresses tumorigenesis through p53-dependent and p53-independent pathways. Most of ARF's anti-proliferative activity is conferred by sequences in its first exon. Previous work showed specific amino acid changes occurred in that region during primate evolution, so we programmed those changes into human p14ARF to assay their functional impact. Two human p14ARF residues (Ala(14) and Thr(31)) were found to destabilize the protein while two others (Val(24) and Ala(41)) promoted more efficient p53 stabilization and activation. Despite those effects, all modified p14ARF forms displayed robust p53-dependent anti-proliferative activity demonstrating there are no significant biological differences in p53-mediated growth suppression associated with simian versus human p14ARF residues. In contrast, p53-independent p14ARF function was considerably altered by several residue changes. Val(24) was required for p53-independent growth suppression whereas multiple residues (Val(24), Thr(31), Ala(41) and His(60)) enabled p14ARF to block or reverse the inherent chromosomal instability of p53-null MEFs. Together, these data pinpoint specific residues outside of established p14ARF functional domains that influence its expression and signaling activities. Most intriguingly, this work reveals a novel and direct role for p14ARF in the p53-independent maintenance of genomic stability.
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Registered trials
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