ArticleLipids in health and disease2009
Increased body mass and depressive symptomatology are associated with hypercholesterolemia, among elderly individuals; results from the MEDIS study.
Article in Lipids in health and disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 55 citations in OpenAlex.
- Association of depressive disorder with biochemical and anthropometric indices in adult men and women.Scientific reports · 2021Trial
- Potential Shared Immunometabolic Signatures Between Familial Hypercholesterolemia and Major Depressive Disorder: Integrative Transcriptomic Analysis, Mendelian Randomization, and Clinical Validation.International journal of molecular sciences · 2026Article
- Metformin Ameliorates Cognitive Deficits and Neuroinflammation in a Mouse Model of Familial Hypercholesterolemia.Neurochemical research · 2026Article
- Demographics, Comorbidities, and Care-Seeking Intent Among Individuals with Obesity or Overweight Status Using Outpatient AI-Based Virtual Triage.Telemedicine reports · 2025Article
- Depression and Anxiety in Old Age during the COVID-19 Pandemic: A Comparative Study of Individuals at Cardiovascular Risk and the General Population.International journal of environmental research and public health · 2023Article
- Relationship between depressive disorders and biochemical indicators in adult men and women.BMC psychiatry · 2023Article
- Association of serum alkaline phosphatase and depression in US adults: a population-based cross-sectional study.Frontiers in psychiatry · 2023Article
- Mental and somatic comorbidity of depression: a comprehensive cross-sectional analysis of 202 diagnosis groups using German nationwide ambulatory claims data.BMC psychiatry · 2020Article
- Morus nigra and its major phenolic, syringic acid, have antidepressant-like and neuroprotective effects in mice.Metabolic brain disease · 2017Article
- Total serum cholesterol, atherogenic indices and their longitudinal association with depressive symptoms among US adults.Translational psychiatry · 2015Article
- Assessing factors related to waist circumference and obesity: application of a latent variable model.Journal of environmental and public health · 2015Article
- Association between lipid profile and depressive symptoms among Chinese older people: mediation by cardiovascular diseases?International journal of behavioral medicine · 2014Article
- Diabetes type II: a risk factor for depression-Parkinson-Alzheimer?Neurotoxicity research · 2011Review
- Lessons from studies in middle-aged and older adults living in mediterranean islands: the role of dietary habits and nutrition services.Cardiology research and practice · 2010Article
- Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression.Progress in neurobiology · 2010Review
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11 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHypercholesterolemia is one of the most important factors causing cardiovascular disease (CVD). The aim of the present work was to evaluate the relationships between socio-demographic, clinical, lifestyle and depression status and the presence of hypercholesterolemia, among elderly individuals without known CVD.
methodsDuring 2005-2007, 1190 elderly (aged 65 to 100 years) men and women (from Cyprus, Mitilini, Samothraki, Cephalonia, Crete, Lemnos, Corfu and Zakynthos) were enrolled. Socio-demographic, clinical and lifestyle factors were assessed through standard procedures. Symptoms of depression were evaluated using the short-form of the Geriatric Depression Scale (GDS, range 0-15). Dietary habits were assessed through a semi-quantitative food frequency questionnaire. Hypercholesterolemia was defined as total serum cholesterol > 200 mg/dL or use of lipids lowering medication.
results44.6% of males and 61.9% of females had hypercholesterolemia (p < 0.001). Only, 63% of hypercholesterolemic participants were under special diet or pharmaceutical treatment. Hypercholisterolemic individuals had higher prevalence of obesity (43% vs. 25%), hypertension (76% vs. 57%) and diabetes (25% vs. 17%) compared with normal participants (p < 0.001). Furthermore, hypercholisterolemic participants showed higher depression levels (p = 0.002). After adjusting for various confounders, GDS score and BMI correlated with 13% (95%CI 0.98-1.30) and 14% (95%CI 0.99-1.31) higher likelihood of having hypercholesterolemia.
conclusionA considerable proportion of our elderly sample had hypercholesterolemia, while 1/3 of them were untreated. Furthermore, presence of hypercholesterolemia was correlated with depressive symptomatology and increased BMI.
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