ArticleJournal of cellular biochemistry2009
Is Runx a linchpin for developmental signaling in metazoans?
Article in Journal of cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- The Brain's Microvascular Response to High Glycemia and to the Inhibition of Soluble Epoxide Hydrolase Is Sexually Dimorphic.Nutrients · 2022Article
- Article
- Unique N-terminal sequences in two Runx1 isoforms are dispensable for Runx1 function.BMC developmental biology · 2017Article
- LRG1 promotes proliferation and inhibits apoptosis in colorectal cancer cells via RUNX1 activation.PloS one · 2017Article
- An Elk transcription factor is required for Runx-dependent survival signaling in the sea urchin embryo.Developmental biology · 2016Article
- Runx2 contributes to the regenerative potential of the mammary epithelium.Scientific reports · 2015Article
- The RUNX family: developmental regulators in cancer.Nature reviews. Cancer · 2015Review
- Heterogeneous generation of new cells in the adult echinoderm nervous system.Frontiers in neuroanatomy · 2015Article
- Sea urchin akt activity is Runx-dependent and required for post-cleavage stage cell division.Biology open · 2013Article
- Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Runx1 is a tumor suppressor gene in the mouse gastrointestinal tract.Cancer science · 2012Article
- ODAM Expression Inhibits Human Breast Cancer Tumorigenesis.Breast cancer : basic and clinical research · 2011Article
- The Runx transcriptional co-activator, CBFbeta, is essential for invasion of breast cancer cells.Molecular cancer · 2010Article
- A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.Molecular and cellular biology · 2010Article
- The evolution of Runx genes II. The C-terminal Groucho recruitment motif is present in both eumetazoans and homoscleromorphs but absent in a haplosclerid demosponge.BMC research notes · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The Runt domain (Runx) is a 128 amino acid sequence motif that defines a metazoan family of sequence-specific DNA binding proteins, which appears to have originated in concert with the intercellular signaling systems that coordinate multicellular development in animals. In the model organisms where they have been studied (fruit fly, mouse, sea urchin, and nematode) Runx genes are essential for normal development, and in humans they are causally associated with a variety of cancers, manifesting both oncogenic and tumor suppressive attributes. During development Runx proteins support both cell proliferation and differentiation, and function in both transcriptional activation and repression. Runx function is thus context-dependent, with the context provided genetically by cis-regulatory sequence architecture and epigenetically by development. This context dependency makes it difficult to formulate reductionistic generalizations concerning Runx function in normal and carcinogenic development. However, a growing body of literature links Runx function to each of the major intercellular signaling systems in animals, suggesting that the general function of Runx transcription factors may be to potentiate and govern genomic responsiveness to developmental signaling.
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