ReviewClinical and experimental hypertension (New York, N.Y. : 1993)2009
Reactive oxygen species and dopamine receptor function in essential hypertension.
Review in Clinical and experimental hypertension (New York, N.Y. : 1993), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Differential Response to Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Reduced or Preserved Ejection Fraction: Results From the ROSE AHF Trial (Renal Optimization Strategies Evaluation in Acute Heart Failure).Circulation. Heart failure · 2016Trial
- Peripartum hypophosphatemia is associated with a hindgut-centered microbiota-metabolite-host axis in transition dairy cows.NPJ biofilms and microbiomes · 2026Article
- Neuroprotective effects of alpha-pinene against behavioral deficits in ketamine-induced mice model of schizophrenia: Focusing on oxidative stress status.IBRO neuroscience reports · 2024Article
- Peroxiredoxin-4 and Dopamine D5 Receptor Interact to Reduce Oxidative Stress and Inflammation in the Kidney.Antioxidants & redox signaling · 2023Article
- Role of Free Catecholamine in Thiol-Ene Crosslinking for Hyaluronic Acid Hydrogels with High Loading Efficiency of Anticancer Drugs.Tissue engineering and regenerative medicine · 2022Article
- Coordinated Contribution of NADPH Oxidase- and Mitochondria-Derived Reactive Oxygen Species in Metabolic Syndrome and Its Implication in Renal Dysfunction.Frontiers in pharmacology · 2021Review
- Effects of Sheetali and Sheetkari Pranayamas on Blood Pressure and Autonomic Function in Hypertensive Patients.Integrative medicine (Encinitas, Calif.) · 2017Article
- Stimulation of Dopamine D3 Receptor Attenuates Renal Ischemia-Reperfusion Injury via Increased Linkage With Gα12.Transplantation · 2015Article
- Renal dopaminergic system: Pathophysiological implications and clinical perspectives.World journal of nephrology · 2015Review
- Anti-hypertensive Herbs and their Mechanisms of Action: Part I.Frontiers in pharmacology · 2015Review
- Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells.Clinical biochemistry · 2014Article
- Regulation of renalase expression by D5 dopamine receptors in rat renal proximal tubule cells.American journal of physiology. Renal physiology · 2014Article
- Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats.Kidney international · 2014Article
- Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells.Redox biology · 2014Article
- Cross talk between ceramide and redox signaling: implications for endothelial dysfunction and renal disease.Handbook of experimental pharmacology · 2013Review
- Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its management.American journal of physiology. Renal physiology · 2012Review
- Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine.European journal of pharmacology · 2012Article
- Intrarenal dopamine modulates progressive angiotensin II-mediated renal injury.American journal of physiology. Renal physiology · 2012Article
- Lipid raft redox signaling: molecular mechanisms in health and disease.Antioxidants & redox signaling · 2011Review
- AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.Cell metabolism · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Essential hypertension is a major risk factor for stroke, myocardial infarction, and heart and kidney failure. Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones and humoral factors. However, the mechanisms leading to impaired dopamine receptor function in hypertension states are not clear. Compelling experimental evidence indicates a role of reactive oxygen species (ROS) in hypertension, and there are increasing pieces of evidence showing that in conditions associated with oxidative stress, which is present in hypertensive states, dopamine receptor effects, such as natriuresis, diuresis, and vasodilation, are impaired. The goal of this review is to present experimental evidence that has led to the conclusion that decreased dopamine receptor function increases ROS activity and vice versa. Decreased dopamine receptor function and increased ROS production, working in concert or independent of each other, contribute to the pathogenesis of essential hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.