Evidence map›Paper›PMID 19330286›Full record

ReviewThe journal of headache and pain2009

Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review.

Peer Tfelt-Hansen, Han Le

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of headache and pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Calcitonin Gene-Related Peptide Ameliorates Experimental Dry Eye Disease.Investigative ophthalmology & visual science · 2025
    Article
  5. Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024
    Review
  6. Molecular Mechanisms of Migraine: Nitric Oxide Synthase and Neuropeptides.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Review
  9. The role of anti-CGRP antibodies in the pathophysiology of primary headaches.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
    Review
  10. Action mechanisms of Onabotulinum toxin-A: hints for selection of eligible patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
    Review
  11. CGRP as a neuropeptide in migraine: lessons from mice.British journal of clinical pharmacology · 2015
    Review
  12. Review
  13. Calcitonin gene-related peptide (CGRP): a new target for migraine.Annual review of pharmacology and toxicology · 2015
    Review
  14. Review
  15. Article
  16. Review
  17. Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT(1B/D) agonist.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012
    Article
  18. Brain-derived neurotrophic factor in primary headaches.The journal of headache and pain · 2012
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peer Tfelt-HansenDepartment of Neurology, Danish Headache Centre, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark. ptha@glo.regionh.dk
Han Le
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The involvement of calcitonin gene-related peptide (CGRP) in migraine pathophysiological mechanisms is shown by the facts that CGRP can induce migraine and that two CGRP antagonists, olcegepant and telcagepant, are effective in the treatment of migraine attacks. Increase of the neuropeptide CGRP during migraine and cluster headache attacks in the extracerebral circulation as measured in the external jugular vein (EJV) has been regarded as an established fact. Then in 2005, a study, using the migraine patients as their own controls, showed; however, no changes of CGRP in EJV. For migraine there is thus some uncertainty as to whether CGRP is increased in all migraine patients and more research is needed. In contrast, there are three 'positive' studies in cluster headache in which both sumatriptan, O(2) and spontaneous resolution normalized CGRP. The source of an increase of CGRP in EJV is most likely a 'nervous vasodilatory drive' in the extracranial vascular bed. It remains an enigma how the observed increase of CGRP in the EJV fits into the mechanisms of migraine and cluster headache.

Indexed as

AnimalsCalcitonin Gene-Related PeptideCluster HeadacheHumansJugular VeinsMigraine DisordersCalcitonin Gene-Related Peptide

Identifiers

PMID19330286
PMCPMC3451987
OpenAlexW2141333443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.