ArticleNonlinearity in biology, toxicology, medicine2005
Nonlinear response for neoplastic transformation following low doses of low let radiation.
Article in Nonlinearity in biology, toxicology, medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- O-Arm-Navigated, Robot-Assisted Versus Conventional CT Guided Radiofrequency Ablation in Treatment of Osteoid Osteoma: A Retrospective Cohort Study.Frontiers in surgery · 2022Article
- Low-dose or low-dose-rate ionizing radiation-induced bioeffects in animal models.Journal of radiation research · 2017Review
- Radiation hormesis: historical perspective and implications for low-dose cancer risk assessment.Dose-response : a publication of International Hormesis Society · 2010Article
- Non-problematic risks from low-dose radiation-induced DNA damage clusters.Dose-response : a publication of International Hormesis Society · 2008Article
- It's time for a new low-dose-radiation risk assessment paradigm--one that acknowledges hormesis.Dose-response : a publication of International Hormesis Society · 2008Article
- Sparsely ionizing diagnostic and natural background radiations are likely preventing cancer and other genomic-instability-associated diseases.Dose-response : a publication of International Hormesis Society · 2006Article
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1 author.
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Abstract
There are now several independent studies that indicate that the dose-response for the endpoint of radiation-induced neoplastic transformation in vitro is non-linear for low linear energy transfer (LET) radiation. At low doses (<10 cGy) the transformation frequency drops below that seen spontaneously. Importantly, this observation has been made using fluoroscopic energy x-rays, a commonly used modality in diagnostic radiology, the practice of which is responsible for the majority of radiation exposure to the general public. Since the transformation frequency is reduced over a large dose range (0.1 to 10cGy) it is likely that multiple mechanisms are involved and that the relative contribution of these may vary with dose. These include the killing of a subpopulation of cells prone to spontaneous transformation at the lowest doses, and the induction of DNA repair at somewhat higher doses. Protective effects of low doses of low LET radiation on other cancer-relevant endpoints in vitro and in vivo have also been observed by several independent laboratories. These observations strongly suggest that the linear-nonthreshold dose-response model is unlikely to apply to the induction of cancer by low doses of low LET radiation in humans.
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