ArticleNonlinearity in biology, toxicology, medicine2004
Low-dose radiation and genotoxic chemicals can protect against stochastic biological effects.
Article in Nonlinearity in biology, toxicology, medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Mechanistic Effects of Environmental and Medical Low-Dose Radiation Exposure of the Lung.Biomedicines · 2026Review
- REVIEW OF QUANTITATIVE MECHANISTIC MODELS OF RADIATION-INDUCED NON-TARGETED EFFECTS (NTE).Radiation protection dosimetry · 2020Review
- Modeling DNA double-strand break repair kinetics as an epiregulated cell-community-wide (epicellcom) response to radiation stress.Dose-response : a publication of International Hormesis Society · 2011Article
- It's time for a new low-dose-radiation risk assessment paradigm--one that acknowledges hormesis.Dose-response : a publication of International Hormesis Society · 2008Article
- Detrimental and protective bystander effects: a model approach.Radiation research · 2007Article
- Protective bystander effects simulated with the state-vector model.Dose-response : a publication of International Hormesis Society · 2007Article
- Low-dose radiation-induced protective process and implications for risk assessment, cancer prevention, and cancer therapy.Dose-response : a publication of International Hormesis Society · 2007Article
- Sparsely ionizing diagnostic and natural background radiations are likely preventing cancer and other genomic-instability-associated diseases.Dose-response : a publication of International Hormesis Society · 2006Article
- Stochastic thresholds: a novel explanation of nonlinear dose-response relationships for stochastic radiobiological effects.Dose-response : a publication of International Hormesis Society · 2006Article
- Low-LET-induced radioprotective mechanisms within a stochastic two-stage cancer model.Dose-response : a publication of International Hormesis Society · 2006Article
- An examination of radiation hormesis mechanisms using a multistage carcinogenesis model.Nonlinearity in biology, toxicology, medicine · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A protective apoptosis-mediated (PAM) process that is turned on in mammalian cells by low-dose photon (X and gamma) radiation and appears to also be turned on by the genotoxic chemical ethylene oxide is discussed. Because of the PAM process, exposure to low-dose photon radiation (and possibly also some genotoxic chemicals) can lead to a reduction in the risk of stochastic effects such as problematic mutations, neoplastic transformation (an early step in cancer occurrence), and cancer. These findings indicate a need to revise the current low-dose risk assessment paradigm for which risk of cancer is presumed to increase linearly with dose (without a threshold) after exposure to any amount of a genotoxic agent such as ionizing radiation. These findings support a view seldom mentioned in the past, that cancer risk can actually decrease, rather than increase, after exposure to low doses of photon radiation and possibly some other genotoxic agents. The PAM process (a form of natural protection) may contribute substantially to cancer prevention in humans and other mammals. However, new research is needed to improve our understanding of the process. The new research could unlock novel strategies for optimizing cancer prevention and novel protocols for low-dose therapy for cancer. With low-dose cancer therapy, normal tissue could be spared from severe damage while possibly eliminating the cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.