ArticleNonlinearity in biology, toxicology, medicine2003
Mechanistic basis for nonlinear dose-response relationships for low-dose radiation-induced stochastic effects.
Article in Nonlinearity in biology, toxicology, medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Mechanistic Effects of Environmental and Medical Low-Dose Radiation Exposure of the Lung.Biomedicines · 2026Review
- Current management strategies for sarcopenia and frailty in cirrhosis: Missing link in transplant candidacy.World journal of hepatology · 2026Review
- Nanoparticle-Mediated Radiotherapy: Unraveling Dose Enhancement and Apoptotic Responses in Cancer and Normal Cell Lines.Biomolecules · 2023Article
- REVIEW OF QUANTITATIVE MECHANISTIC MODELS OF RADIATION-INDUCED NON-TARGETED EFFECTS (NTE).Radiation protection dosimetry · 2020Review
- Advancing risk assessment: mechanistic dose-response modelling ofRoyal Society open science · 2018Article
- Comments on "Incidence of cancer among licensed commercial pilots flying North Atlantic routes".Environmental health : a global access science source · 2017Article
- Emerging targets for radioprotection and radiosensitization in radiotherapy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Non-linear adaptive phenomena which decrease the risk of infection after pre-exposure to radiofrequency radiation.Dose-response : a publication of International Hormesis Society · 2014Article
- The cellular and molecular carcinogenic effects of radon exposure: a review.International journal of molecular sciences · 2013Review
- Low-dose-radiation stimulated natural chemical and biological protection against lung cancer.Dose-response : a publication of International Hormesis Society · 2008Article
- Detrimental and protective bystander effects: a model approach.Radiation research · 2007Article
- Protective bystander effects simulated with the state-vector model.Dose-response : a publication of International Hormesis Society · 2007Article
- Low-dose radiation-induced protective process and implications for risk assessment, cancer prevention, and cancer therapy.Dose-response : a publication of International Hormesis Society · 2007Article
- Radiation-induced neoplastic transformation in vitro, hormesis and risk assessment.Dose-response : a publication of International Hormesis Society · 2006Article
- Suppression of neoplastic transformation in vitro by low doses of low LET radiation.Dose-response : a publication of International Hormesis Society · 2006Article
- Low-LET-induced radioprotective mechanisms within a stochastic two-stage cancer model.Dose-response : a publication of International Hormesis Society · 2006Article
- Stochastic thresholds: a novel explanation of nonlinear dose-response relationships for stochastic radiobiological effects.Dose-response : a publication of International Hormesis Society · 2006Article
- Nonlinear response for neoplastic transformation following low doses of low let radiation.Nonlinearity in biology, toxicology, medicine · 2005Article
- An examination of radiation hormesis mechanisms using a multistage carcinogenesis model.Nonlinearity in biology, toxicology, medicine · 2004Article
- Low-dose radiation and genotoxic chemicals can protect against stochastic biological effects.Nonlinearity in biology, toxicology, medicine · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The linear nonthreshold (LNT) model plays a central role in low-dose radiation risk assessment for humans. With the LNT model, any radiation exposure is assumed to increase one's risk of cancer. Based on the LNT model, others have predicted tens of thousands of deaths related to environmental exposure to radioactive material from nuclear accidents (e.g., Chernobyl) and fallout from nuclear weapons testing. Here, we introduce a mechanism-based model for low-dose, radiation-induced, stochastic effects (genomic instability, apoptosis, mutations, neoplastic transformation) that leads to a LNT relationship between the risk for neoplastic transformation and dose only in special cases. It is shown that nonlinear dose-response relationships for risk of stochastic effects (problematic nonlethal mutations, neoplastic transformation) should be expected based on known biological mechanisms. Further, for low-dose, low-dose rate, low-LET radiation, large thresholds may exist for cancer induction. We summarize previously published data demonstrating large thresholds for cancer induction. We also provide evidence for low-dose-radiation-induced, protection (assumed via apoptosis) from neoplastic transformation. We speculate based on work of others (Chung 2002) that such protection may also be induced to operate on existing cancer cells and may be amplified by apoptosis-inducing agents such as dietary isothiocyanates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.