ReviewCell adhesion & migration
Semaphorin signals on the road to cancer invasion and metastasis.
Review in Cell adhesion & migration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Association between prognosis and SEMA4D/Plexin-B1 expression in various malignancies: A meta-analysis.Medicine · 2019Pooled it
- Acidic melanoma microenvironment selects for a senescence-like but also migratory-active subpopulation driving metastatic disease.Cell death discovery · 2025Article
- Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring.Nature communications · 2024Article
- ESRP1-regulated isoform switching of LRRFIP2 determines metastasis of gastric cancer.Nature communications · 2022Article
- Analysis of Collagen type X alpha 1 (COL10A1) expression and prognostic significance in gastric cancer based on bioinformatics.Bioengineered · 2021Article
- Sema3C promotes hepatic metastasis and predicts poor prognosis in gastric adenocarcinoma.The Journal of international medical research · 2021Article
- The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs.Toxicology research · 2020Article
- Article
- Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis.Oncotarget · 2018Article
- The association of semaphorin 5A with lymph node metastasis and adverse prognosis in cervical cancer.Cancer cell international · 2018Article
- Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF-7 breast cancer cells.Oncology letters · 2017Article
- Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications.Arthritis & rheumatology (Hoboken, N.J.) · 2015Article
- Semaphorin 5A mediated cellular navigation: connecting nervous system and cancer.Biochimica et biophysica acta · 2014Review
- Role of the nervous system in cancer metastasis.Oncology letters · 2013Article
- MICAL, the flavoenzyme participating in cytoskeleton dynamics.International journal of molecular sciences · 2013Review
- Molecular profiling of the "plexinome" in melanoma and pancreatic cancer.Human mutation · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Semaphorins are a large family of secreted and membrane-bound molecules initially implicated in the development of the nervous system and in axon guidance. More recently, they have been found to regulate cell adhesion and cell motility, angiogenesis, immune function and tumour progression. Notably, Semaphorins have been implicated with opposite functions in cancer: either as putative tumor suppressors and anti-angiogenic factors, or as mediating tumour angiogenesis, invasion and metastasis. Interestingly, Semaphorins may display divergent activities in different cell types. These multifaceted functions may be explained by the involvement of different kinds of semaphorin receptor complexes, and by the consequent activation of multiple signaling pathways, in different cells or different functional stages. Semaphorin signaling is largely mediated by the Plexins. However, semaphorin receptor complexes may also include Neuropilins and tyrosine kinases implicated in cancer. In this review, we will focus on major open questions concerning the potential role of Semaphorin signals in cancer.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.