ReviewJournal of cardiovascular pharmacology and therapeutics2009
p130 Crk-associated substrate (CAS) in vascular smooth muscle.
Review in Journal of cardiovascular pharmacology and therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- The intermediate filament protein nestin serves as a molecular hub for smooth muscle cytoskeletal signaling.Respiratory research · 2023Article
- Reorganization of the Vimentin Network in Smooth Muscle.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- Role and regulation of Abelson tyrosine kinase in Crk-associated substrate/profilin-1 interaction and airway smooth muscle contraction.Respiratory research · 2018Article
- The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration.Respiratory research · 2017Review
- Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.The Journal of clinical investigation · 2017Article
- Polo-like Kinase 1 Regulates Vimentin Phosphorylation at Ser-56 and Contraction in Smooth Muscle.The Journal of biological chemistry · 2016Article
- Vimentin dephosphorylation at ser-56 is regulated by type 1 protein phosphatase in smooth muscle.Respiratory research · 2016Article
- Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling.Respiratory research · 2015Review
- Non-receptor tyrosine kinases and the actin cytoskeleton in contractile vascular smooth muscle.The Journal of physiology · 2015Review
- Review
- Recruitment of β-catenin to N-cadherin is necessary for smooth muscle contraction.The Journal of biological chemistry · 2015Article
- Glia maturation factor-γ phosphorylation at Tyr-104 regulates actin dynamics and contraction in human airway smooth muscle.American journal of respiratory cell and molecular biology · 2014Article
- Histone deacetylase 8 regulates cortactin deacetylation and contraction in smooth muscle tissues.American journal of physiology. Cell physiology · 2014Article
- The association of cortactin with profilin-1 is critical for smooth muscle contraction.The Journal of biological chemistry · 2014Article
- Role of c-Abl tyrosine kinase in smooth muscle cell migration.American journal of physiology. Cell physiology · 2014Article
- Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease.PloS one · 2014Article
- Raf-1, actin dynamics, and abelson tyrosine kinase in human airway smooth muscle cells.American journal of respiratory cell and molecular biology · 2013Article
- Abl activation regulates the dissociation of CAS from cytoskeletal vimentin by modulating CAS phosphorylation in smooth muscle.American journal of physiology. Cell physiology · 2010Article
- Role of p47(phox) in regulating Cdc42GAP, vimentin, and contraction in smooth muscle cells.American journal of physiology. Cell physiology · 2009Article
- Abl knockout differentially affects p130 Crk-associated substrate, vinculin, and paxillin in blood vessels of mice.American journal of physiology. Heart and circulatory physiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Vascular smooth muscle is a key effector in the wall of blood vessels during the pathogenesis of hypertension. Various factors directly elicit smooth muscle cell contraction, migration, growth, and hypertrophy, which lead to the progression of hypertension. Crk-associated substrate (CAS), the first discovered member of the adapter protein CAS family, has recently emerged as a critical cellular component that regulates smooth muscle functions. In this review, the molecular structure and protein interactions of the CAS family members are summarized. Evidence for the role of CAS in the regulation of vascular smooth muscle contractility, cell migration, hypertrophy, and growth is presented. Regulation of CAS by novel tyrosine kinases/phosphatases and unique downstream signaling partners of CAS are also discussed. These new findings establish the important role for CAS in regulating vascular smooth muscle functions. The CAS-associated processes may be new biological targets for the development of new treatment of cardiovascular diseases such as hypertension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.