ArticleJournal of bacteriology2009
Identification and characterization of OscR, a transcriptional regulator involved in osmolarity adaptation in Vibrio cholerae.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Bacterial type VI secretion system (T6SS): an evolved molecular weapon with diverse functionality.Biotechnology letters · 2023Review
- Type VI Secretion Systems: Environmental and Intra-host Competition of Vibrio cholerae.Advances in experimental medicine and biology · 2023Article
- Insights into theAntibiotics (Basel, Switzerland) · 2022Article
- A diguanylate cyclase regulates biofilm formation in3 Biotech · 2022Article
- Stressed out: Bacterial response to high salinity using compatible solute biosynthesis and uptake systems, lessons fromComputational and structural biotechnology journal · 2021Review
- On or Off: Life-Changing Decisions Made byInfectious microbes & diseases · 2020Review
- Vibrio cholerae OmpR Contributes to Virulence Repression and Fitness at Alkaline pH.Infection and immunity · 2020Article
- Development of Ratiometric Bioluminescent Sensors forACS chemical biology · 2020Article
- Vibrio cholerae OmpR Represses the ToxR Regulon in Response to Membrane Intercalating Agents That Are Prevalent in the Human Gastrointestinal Tract.Infection and immunity · 2020Article
- Quorum Sensing as a Target for Controlling Surface Associated Motility and Biofilm Formation inFrontiers in microbiology · 2020Article
- Growth arrest and a persister state enable resistance to osmotic shock and facilitate dissemination of Vibrio cholerae.The ISME journal · 2017Article
- Spermine inhibitsThe Journal of biological chemistry · 2017Article
- The Two-Component Signal Transduction System VxrAB Positively Regulates Vibrio cholerae Biofilm Formation.Journal of bacteriology · 2017Article
- Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion.Nature communications · 2017Article
- Rules of Engagement: The Type VI Secretion System in Vibrio cholerae.Trends in microbiology · 2017Review
- The Outer Membrane Protein OmpW EnhancedFrontiers in microbiology · 2017Article
- A novel phase variant of the cholera pathogen shows stress-adaptive cryptic transcriptomic signatures.BMC genomics · 2016Article
- Staying Alive: Vibrio cholerae's Cycle of Environmental Survival, Transmission, and Dissemination.Microbiology spectrum · 2016Review
- Microbial Surface Colonization and Biofilm Development in Marine Environments.Microbiology and molecular biology reviews : MMBR · 2016Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vibrio cholerae is a facultative human pathogen. In its aquatic habitat and as it passes through the digestive tract, V. cholerae must cope with fluctuations in salinity. We analyzed the genome-wide transcriptional profile of V. cholerae grown at different NaCl concentrations and determined that the expression of compatible solute biosynthesis and transporter genes, virulence genes, and genes involved in adhesion and biofilm formation is differentially regulated. We determined that salinity modulates biofilm formation, and this response was mediated through the transcriptional regulators VpsR and VpsT. Additionally, a transcriptional regulator controlling an osmolarity adaptation response was identified. This regulator, OscR (osmolarity controlled regulator), was found to modulate the transcription of genes involved in biofilm matrix production and motility in a salinity-dependent manner. oscR mutants were less motile and exhibited enhanced biofilm formation only under low-salt conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.