ArticlePlant physiology2009
Epistatic interactions between Opaque2 transcriptional activator and its target gene CyPPDK1 control kernel trait variation in maize.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Review
- Storage protein activator controls grain protein accumulation in bread wheat in a nitrogen dependent manner.Scientific reports · 2023Article
- Plant biochemical genetics in the multiomics era.Journal of experimental botany · 2023Review
- Genome-wide association and epistasis studies reveal the genetic basis of saline-alkali tolerance at the germination stage in rice.Frontiers in plant science · 2023Article
- Encoded CPlant signaling & behavior · 2022Review
- SNP-Based Genome-Wide Association Mapping of Pollen Viability Under Heat Stress in TropicalFrontiers in genetics · 2022Article
- Genome wide association mapping for heat tolerance in sub-tropical maize.BMC genomics · 2021Article
- Cytosolic malate dehydrogenase 4 modulates cellular energetics and storage reserve accumulation in maize endosperm.Plant biotechnology journal · 2020Article
- Over-ExpressingInternational journal of molecular sciences · 2020Article
- OPAQUE11 Is a Central Hub of the Regulatory Network for Maize Endosperm Development and Nutrient Metabolism.The Plant cell · 2018Article
- Article
- General and specific combining abilities in a maize (Zea mays L.) test-cross hybrid panel: relative importance of population structure and genetic divergence between parents.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- Proteomic profiling of maize opaque endosperm mutants reveals selective accumulation of lysine-enriched proteins.Journal of experimental botany · 2016Article
- Genomic Regions Associated with Root Traits under Drought Stress in Tropical Maize (Zea mays L.).PloS one · 2016Article
- Functional mechanisms of drought tolerance in subtropical maize (Zea mays L.) identified using genome-wide association mapping.BMC genomics · 2014Article
- Identification of promoter motifs regulating ZmeIF4E expression level involved in maize rough dwarf disease resistance in maize (Zea Mays L.).Molecular genetics and genomics : MGG · 2013Article
- Application of genomic tools in plant breeding.Current genomics · 2012Article
- Maize genetic diversity and association mapping using transposable element insertion polymorphisms.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Article
- Genetic architecture of maize kernel composition in the nested association mapping and inbred association panels.Plant physiology · 2012Article
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14 authors.
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Abstract
Association genetics is a powerful method to track gene polymorphisms responsible for phenotypic variation, since it takes advantage of existing collections and historical recombination to study the correlation between large genetic diversity and phenotypic variation. We used a collection of 375 maize (Zea mays ssp. mays) inbred lines representative of tropical, American, and European diversity, previously characterized for genome-wide neutral markers and population structure, to investigate the roles of two functionally related candidate genes, Opaque2 and CyPPDK1, on kernel quality traits. Opaque2 encodes a basic leucine zipper transcriptional activator specifically expressed during endosperm development that controls the transcription of many target genes, including CyPPDK1, which encodes a cytosolic pyruvate orthophosphate dikinase. Using statistical models that correct for population structure and individual kinship, Opaque2 polymorphism was found to be strongly associated with variation of the essential amino acid lysine. This effect could be due to the direct role of Opaque2 on either zein transcription, zeins being major storage proteins devoid of lysine, or lysine degradation through the activation of lysine ketoglutarate reductase. Moreover, we found that a polymorphism in the Opaque2 coding sequence and several polymorphisms in the CyPPDK1 promoter nonadditively interact to modify both lysine content and the protein-versus-starch balance, thus revealing the role in quantitative variation in plants of epistatic interactions between a transcriptional activator and one of its target genes.
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