ArticleThe Journal of biological chemistry2009
Recombination activator function of the novel RAD51- and RAD51B-binding protein, human EVL.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- The impact of DNA methylation on the cancer proteome.PLoS computational biology · 2019Article
- RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency.Nature communications · 2016Article
- Identifying network biomarkers based on protein-protein interactions and expression data.BMC medical genomics · 2015Article
- Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous pairing.Nucleic acids research · 2012Article
- Novel genetic markers of breast cancer survival identified by a genome-wide association study.Cancer research · 2012Article
- Fine mapping of 14q24.1 breast cancer susceptibility locus.Human genetics · 2012Article
- Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12.Neuro-oncology · 2012Article
- Inflammatory transcriptome profiling of human monocytes exposed acutely to cigarette smoke.PloS one · 2012Article
- Single-stranded DNA catenation mediated by human EVL and a type I topoisomerase.Nucleic acids research · 2010Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The RAD51 protein is a central player in homologous recombinational repair. The RAD51B protein is one of five RAD51 paralogs that function in the homologous recombinational repair pathway in higher eukaryotes. In the present study, we found that the human EVL (Ena/Vasp-like) protein, which is suggested to be involved in actin-remodeling processes, unexpectedly binds to the RAD51 and RAD51B proteins and stimulates the RAD51-mediated homologous pairing and strand exchange. The EVL knockdown cells impaired RAD51 assembly onto damaged DNA after ionizing radiation or mitomycin C treatment. The EVL protein alone promotes single-stranded DNA annealing, and the recombination activities of the EVL protein are further enhanced by the RAD51B protein. The expression of the EVL protein is not ubiquitous, but it is significantly expressed in breast cancer-derived MCF7 cells. These results suggest that the EVL protein is a novel recombination factor that may be required for repairing specific DNA lesions, and that may cause tumor malignancy by its inappropriate expression.
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