ArticleNeuroscience2009
Differential noxious and motor tolerance of chronic delta opioid receptor agonists in rodents.
Article in Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- Single Cell Transcriptomic Analysis of Spinal Dmrt3 Neurons in Zebrafish and Mouse Identifies Distinct Subtypes and Reveal Novel Subpopulations Within the dI6 Domain.Frontiers in cellular neuroscience · 2021Article
- Ligand-specific recycling profiles determine distinct potential for chronic analgesic tolerance of delta-opioid receptor (DOPr) agonists.Journal of cellular and molecular medicine · 2020Article
- Alleviating pain with delta opioid receptor agonists: evidence from experimental models.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- The Delta-Opioid Receptor; a Target for the Treatment of Pain.Frontiers in molecular neuroscience · 2020Review
- Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.Neuron · 2018Article
- Sex Differences in Regional Brain Glucose Metabolism Following Opioid Withdrawal and Replacement.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Synthesis and Opioid Activity of TyrChemMedChem · 2017Article
- Imaging Sex Differences in Regional Brain Metabolism during Acute Opioid Withdrawal.Journal of alcoholism and drug dependence · 2017Article
- Article
- Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5.British journal of pharmacology · 2015Article
- Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain.The European journal of neuroscience · 2015Article
- In vivo techniques to investigate the internalization profile of opioid receptors.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Analgesic synergy between opioid and α2 -adrenoceptors.British journal of pharmacology · 2015Review
- Identifying ligand-specific signalling within biased responses: focus on δ opioid receptor ligands.British journal of pharmacology · 2015Review
- Recent advances on the δ opioid receptor: from trafficking to function.British journal of pharmacology · 2015Review
- Stimulation of δ opioid receptor and blockade of nociceptin/orphanin FQ receptor synergistically attenuate parkinsonism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice.British journal of pharmacology · 2014Article
- Antinociceptive tolerance to NSAIDs microinjected into dorsal hippocampus.BMC pharmacology & toxicology · 2014Article
- Endocytic profiles of δ-opioid receptor ligands determine the duration of rapid but not sustained cAMP responses.Molecular pharmacology · 2014Article
- Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity.Bioorganic & medicinal chemistry letters · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
In the present study, we asked whether multiple intrathecal injections of deltorphin II, a selective delta opioid receptor (DOPR) agonist, induced DOPR tolerance in three behavioral assays. Unilateral inflammation caused by complete Freund's adjuvant (CFA) injection into the rat or mouse hind paw (CFA model) induced thermal hyperalgesic response that was transiently and dose-dependently reduced by intrathecal administration of deltorphin II or morphine. In both rodent species, the effect of deltorphin II was not modified by a single prior administration of deltorphin II, suggesting an absence of acute tolerance in this paradigm. Repeated administration of intrathecal deltorphin II or s.c. SB-235863 (five consecutive injections over 60 h) also failed to impair the antihyperalgesic response to delta opioid receptor agonist, whereas repeated intrathecal or s.c. injections of morphine induced a significant decrease in the subsequent thermal antihyperalgesic response to morphine. In mice, deltorphin II also induced a rapid, transient motor incoordination/ataxia-like behavior as tested with the accelerating rotarod. In contrast to the antihyperalgesic responses, tolerance to the motoric effect of deltorphin II was evident in mice previously exposed to multiple intrathecal agonist injections, but not multiple saline administrations. Using the tail flick antinociceptive test, we found that DOPR-mediated analgesia was significantly reduced by repeated exposure to deltorphin II. Altogether, these observations suggest that repeated injections of DOPR agonists induce differential tolerance effects on antihyperalgesic, antinociceptive, and motor incoordination/ataxia-like behaviors related to DOPR activation by deltorphin II.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.