ArticleGastroenterology2009
Nuclear myosin II regulates the assembly of preinitiation complex for ICAM-1 gene transcription.
Article in Gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- Lipopolysaccharide Stimulates A549 Cell Migration through p-Tyr 42 RhoA and Phospholipase D1 Activity.Biomolecules · 2023Article
- Myosin in chromosome organisation and gene expression.Biochemical Society transactions · 2023Review
- Exosomal miR-29b of Gut Origin in Patients With Ulcerative Colitis Suppresses Heart Brain-Derived Neurotrophic Factor.Frontiers in molecular biosciences · 2022Article
- MYH9 binds to dNTPs via deoxyribose moiety and plays an important role in DNA synthesis.Oncotarget · 2022Article
- Behind Brain Metastases Formation: Cellular and Molecular Alterations and Blood-Brain Barrier Disruption.International journal of molecular sciences · 2021Article
- The myosin regulatory light chain Myl5 localizes to mitotic spindle poles and is required for proper cell division.Cytoskeleton (Hoboken, N.J.) · 2021Article
- Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart.PloS one · 2021Article
- Review
- Nuclear MYH9-induced CTNNB1 transcription, targeted by staurosporin, promotes gastric cancer cell anoikis resistance and metastasis.Theranostics · 2020Article
- The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus.Journal of the American Society of Nephrology : JASN · 2019Article
- Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons.Stem cells translational medicine · 2019Article
- N-terminal acetylation and methylation differentially affect the function of MYL9.The Biochemical journal · 2018Article
- Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life.Cellular and molecular gastroenterology and hepatology · 2018Article
- Expression and prognostic significance of MYL9 in esophageal squamous cell carcinoma.PloS one · 2017Article
- The Bidirectional Regulation between MYL5 and HIF-1α Promotes Cervical Carcinoma Metastasis.Theranostics · 2017Article
- Review
- Actin, actin-binding proteins, and actin-related proteins in the nucleus.Histochemistry and cell biology · 2016Review
- Noninflammatory upregulation of nerve growth factor underlies gastric hypersensitivity induced by neonatal colon inflammation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains.Journal of muscle research and cell motility · 2015Article
- Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following cerebral ischemia/reperfusion.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND &
aimsActin-myosin II motor converts chemical energy into force/motion in muscle and nonmuscle cells. The phosphorylation of 20-kilodalton regulatory myosin light chain (MLC(20)) is critical to the cytoplasmic functions of these motors. We do not know whether myosin II and actins in the nucleus function as motors to generate relative motion, such as that between RNA polymerase II holoenzyme and DNA, for assembly of the preinitiation complex.
methodsThe experiments were performed on primary cultures of human colonic circular smooth muscle cells and rat colonic circular muscle strips.
resultsWe show that myosin II and alpha- and beta-actins are present in the nuclei of colonic smooth muscle cells. The nuclear myosin II is tethered to recognition sequence AGCTCC (-39/-34) in the intercellular adhesion molecule 1 (ICAM-1) core promoter region. The actins are known to complex with RNA polymerase II, and they are tethered to the nucleoskeleton. The dephosphorylation of MLC(20) increases the transcription of ICAM-1, whereas its phosphorylation decreases it. Colonic inflammation suppresses nuclear myosin light chain kinase, which increases the unphosphorylated form of nuclear MLC(20), resulting in enhanced transcription of ICAM-1.
conclusionsMyosin II is a core transcription factor. The phosphorylation/dephosphorylation of nuclear MLC(20) results in the sliding of myosin and actin molecules past each other, producing relative motion between DNA bound to the myosin II and RNA polymerase II holoenzyme bound to actins and nucleoskeleton.
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