ArticleBiomaterials2009
The effect of the local delivery of platelet-derived growth factor from reactive two-component polyurethane scaffolds on the healing in rat skin excisional wounds.
Article in Biomaterials, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 150 citations in OpenAlex.
- Heparan sulfate as a central modulator of growth factor dynamics in tissue regeneration.APL bioengineering · 2025Article
- Effect of vascularized jejunal conduit flap on peripheral nerve regeneration in rats.Turkish journal of medical sciences · 2024Article
- Reactive oxygen species-degradable polythioketal urethane foam dressings to promote porcine skin wound repair.Science translational medicine · 2022Article
- Microstructure and Mechanical Properties of PU/PLDL Sponges Intended for Grafting Injured Spinal Cord.Polymers · 2020Article
- Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during Staphylococcus aureus Osteomyelitis.Antimicrobial agents and chemotherapy · 2020Article
- Bone Tissue Regeneration in the Oral and Maxillofacial Region: A Review on the Application of Stem Cells and New Strategies to Improve Vascularization.Stem cells international · 2019Review
- Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds.Experimental and therapeutic medicine · 2018Article
- Drug delivery and tissue engineering to promote wound healing in the immunocompromised host: Current challenges and future directions.Advanced drug delivery reviews · 2018Review
- Effect of Starch Loading on the Thermo-Mechanical and Morphological Properties of Polyurethane Composites.Materials (Basel, Switzerland) · 2017Article
- Recent advances in electrospun nanofibers for wound healing.Nanomedicine (London, England) · 2017Review
- Low-Initial-Modulus Biodegradable Polyurethane Elastomers for Soft Tissue Regeneration.ACS applied materials & interfaces · 2017Article
- Injected biodegradable polyurethane scaffolds support tissue infiltration and delay wound contraction in a porcine excisional model.Journal of biomedical materials research. Part B, Applied biomaterials · 2016Article
- Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic Wound Healing.Advanced healthcare materials · 2016Article
- Nanometer-sized extracellular matrix coating on polymer-based scaffold for tissue engineering applications.Journal of biomedical materials research. Part A · 2016Article
- Substrate modulus of 3D-printed scaffolds regulates the regenerative response in subcutaneous implants through the macrophage phenotype and Wnt signaling.Biomaterials · 2015Article
- Strategies for the chemical and biological functionalization of scaffolds for cardiac tissue engineering: a review.Journal of the Royal Society, Interface · 2015Review
- Drug delivery systems for wound healing.Current pharmaceutical biotechnology · 2015Review
- Tunable delivery of siRNA from a biodegradable scaffold to promote angiogenesis in vivo.Advanced materials (Deerfield Beach, Fla.) · 2014Article
- Biodegradable lysine-derived polyurethane scaffolds promote healing in a porcine full-thickness excisional wound model.Journal of biomaterials science. Polymer edition · 2014Article
- Acoustic droplet-hydrogel composites for spatial and temporal control of growth factor delivery and scaffold stiffness.Acta biomaterialia · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A key tenet of tissue engineering is the principle that the scaffold can perform the dual roles of biomechanical and biochemical support through presentation of the appropriate mediators to surrounding tissue. While growth factors have been incorporated into scaffolds to achieve sustained release, there are a limited number of studies investigating release of biologically active molecules from reactive two-component polymers, which have potential application as injectable delivery systems. In this study, we report the sustained release of platelet-derived growth factor (PDGF) from a reactive two-component polyurethane. The release of PDGF was bi-phasic, characterized by an initial burst followed by a period of sustained release for up to 21 days. Despite the potential for amine and hydroxyl groups in the protein to react with the isocyanate groups in the reactive polyurethane, the in vitro bioactivity of the released PDGF was largely preserved when added as a lyophilized powder. PUR/PDGF scaffolds implanted in rat skin excisional wounds accelerated wound healing relative to the blank PUR control, resulting in almost complete healing with reepithelization at day 14. The presence of PDGF attracted both fibroblasts and mononuclear cells, significantly accelerating degradation of the polymer and enhancing formation of new granulation tissue as early as day 3. The ability of reactive two-component PUR scaffolds to promote new tissue formation in vivo through local delivery of PDGF may present compelling opportunities for the development of novel injectable therapeutics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.