ArticleJournal of autoimmunity
Selective regulation of autoreactive B cells by FcgammaRIIB.
Article in Journal of autoimmunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Evolution of self-reactive B cells: lessons from a lupus model.Biochemical Society transactions · 2026Review
- Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis.Journal of autoimmunity · 2014Article
- High-dose methylprednisolone pulse therapy upregulated FcγRIIb expression on B cells in primary Sjögren's syndrome patients with thrombocytopenia.Clinical rheumatology · 2013Article
- Regulation of allograft survival by inhibitory FcγRIIb signaling.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Generation of gene-engineered chimeric DNA molecules for specific therapy of autoimmune diseases.Human gene therapy methods · 2012Article
- Emerging roles for the interferon-inducible p200-family proteins in sex bias in systemic lupus erythematosus.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2011Review
- Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis.Cellular & molecular immunology · 2011Article
- Lessons from an anti-DNA autoantibody.Molecular immunology · 2011Review
- B cell depletion therapy exacerbates murine primary biliary cirrhosis.Hepatology (Baltimore, Md.) · 2011Article
- Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis.Journal of autoimmunity · 2010Article
- Could the expression of CD86 and FcγRIIB on B cells be functionally related and involved in driving rheumatoid arthritis?Arthritis research & therapy · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
FcgammaRIIB is an inhibitory receptor which plays a role in limiting B cell and DC activation. Since FcgammaRIIB is known to dampen the signaling strength of the BCR, we wished to determine the impact of FcgammaRIIB on the regulation of BCRs which differ in their affinity for DNA. For these studies, FcgammaRIIB deficient BALB/c mice were bred with mice expressing the transgene-encoded H chain of the R4A anti-DNA antibody which gives rise to BCRs which express high, low or no affinity for DNA. The deletion of FcgammaRIIB in R4A BALB/c mice led to an alteration in the B cell repertoire, allowing for the expansion and activation of high affinity DNA-reactive B cells. By 6-8 months of age, R4A x FcgammaRIIB-/- BALB/c mice spontaneously developed anti-DNA antibody titers. These mice also displayed an induction of IFN-inducible genes and an elevation in levels of the B cell survival factor, BAFF. These data demonstrate that FcgammaRIIB preferentially limits activation of high affinity autoreactive B cells and can influence the activation of DC through an immune complex-mediated mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.